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PROFESSOR NEERAJ VIJ
Neeraj Vij, MS, Ph.D. is Assistant Professor,
Institute of Nano Biotechnology,
Johns Hopkins University and
Assistant Professor,
School of Medicine,
Johns Hopkins University.
His expertise and research interests are:
- Protein processing of misfolded dF508 CFTR, alpha-1-antitrypsin Z
mutant and other conformational mutant proteins.
- Functional role of VCP/p97 (AAA ATP chaperone) in ERAD, protein
aggregation and forward trafficking pathways, and identification of
sites for selective interaction and/or post translational modification
for therapeutic intervention.
- Mechanisms of ubiquitination and deubiquitination of misfolded
proteins, and identification of substrate specific ubuitinating ligases
(E1/E2/E3s) and deubiquitinating enzymes (DUBs like Ub C-terminal
hydrolases, UCHs or ubiquitin specific proteases, USPs).
- Chronic airway inflammation with emphasis on the role of PGE-2, IL8
and neutrophil chemotaxis.
- Immune privilege and wound healing
Neeraj coauthored
A Novel Role of the Lumican Core Protein in Bacterial,
Selective Inhibition of Endoplasmic Reticulum-associated Degradation
Rescues ΔF508-Cystic Fibrosis Transmembrane Regulator and
Suppresses Interleukin-8 Levels
Lipopolysaccharide-induced Innate Immune Response,
CHOP Transcription Factor Mediates IL-8 Signaling in Cystic Fibrosis
Bronchial Epithelial Cells,
Pharmacoproteomics of 4-Phenylbutyrate-Treated IB3-1 Cystic Fibrosis
Bronchial Epithelial Cells,
Lumican suppresses cell proliferation and aids Fas?as ligand mediated
apoptosis: implications in the cornea, and
Microarray Studies Reveal Macrophage-like Function of Stromal
Keratocytes in the Cornea.
He earned his M.S. in Microbiology at GK University, India in 1998, was
Research Fellow, Institute of Genetics, BRC, Szeged, Molecular Biology
and Genetics in 2001, earned his Ph.D. in Biotechnology at the
Indian Institute of Technology, Roorkee in 2001, was
Scientific Research Associate, University of Heidelberg, Molecular
Immunology in 2002, and
Postdoctoral Fellow, Johns Hopkins University, Molecular Biology &
Functional Genomics in 2006.
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