Dr. Florian A. SiebzehnrublThe PhysOrg article Scientists find first link in humans between memory and nerve cell production said
Production of new nerve cells in the human brain is linked to learning and memory, according to a new study from the University of Florida. The research is the first to show such a link in humans. The findings, published online and in an upcoming print issue of the journal Brain, provide clues about processes involved in age- and health-related memory loss and reveal potential cellular targets for drug therapy.
The researchers studied how stem cells in a memory-related region of the brain, called the hippocampus, proliferate and change into different types of nerve cells. Scientists have been unsure of the significance of that process in humans.
“The findings suggest that if we can increase the regeneration of nerve cells in the hippocampus we can alleviate or prevent memory loss in humans,” said Florian Siebzehnrubl, a postdoctoral researcher in neuroscience in the UF College of Medicine, and co-first author of the study. “This process gives us what pharmacologists call a ‘druggable target’.”
Florian A. Siebzehnrubl, M.Sc., Ph.D. is
Research Post-Doctoral Associate,
University of Florida,
McKnight Brain Institute.
The focus of his research is therapeutic application of adult neural stem cells in movement disorders. His specialities include adult neural stem cell culture, neurosphere assay, (time-lapse) microscopy, in vivo work, immunohistochemistry, immunocytochemistry, and human cell culture.
His papers include Experimental therapy of malignant gliomas using the inhibitor of histone deacetylase MS-275, The peroxisome proliferator-activated receptor-γ agonist troglitazone inhibits transforming growth factor-β-mediated glioma cell migration and brain invasion, In vitro and ex vivo evaluation of second-generation histone deacetylase inhibitors for the treatment of spinal muscular atrophy, Suberoylanilide hydroxamic acid (SAHA) has potent anti-glioma properties in vitro, ex vivo, and in vivo, and Common mutations of β-catenin in adamantinomatous craniopharyngiomas but not in other tumors originating from the sellar region.
Florian earned his M.Sc. in Molecular Medicine in 2004 and his Ph.D. in Neuroscience in 2007, both at the University of Erlangen Nuremberg (Erlangen, Germany). His Ph.D. dissertation was Therapeutic Applicability of Adult Brain Stem Cells.
Read his LinkedIn profile.