Dr. Evangelos D. MichelakisThe CTV article Small molecule offers hope for cancer treatment said
In findings that “astounded” the researchers, the molecule known as DCA was shown to shrink lung, breast and brain tumors in both animal and human tissue experiments.
“You typically get this eureka type of feeling. It’s the most exciting thing a scientist can get,” Dr. Evangelos Michelakis, a professor at the University of Alberta department of medicine and a key study author, told CTV News.
The study was published Tuesday in the journal Cancer Cell.
The molecule appears to repair the damage that cancer cells cause to mitochondria, the units that convert food into energy.
“Cancer cells actively suppress their mitochondria, which alters their metabolism, and this appears to offer cancer cells a significant advantage in growth compared to normal cells, as well as protection from many standard chemotherapies,” Michelakis said.
Evangelos D. Michelakis, M.D., FACC, FAHA is
Associate Professor of Medicine, University of Alberta, Director,
Pulmonary Hypertension Program,
Dep. Director, Tomorrow’s Research Cardiovascular
Health Professionals, and
Senior Fellow and Founding Member, Pulmonary Vascular Research Institute.
He is also Member, Vascular Biology Group and Director of CIGNET.
He earned his MD from the
University of Patras in 1990.
research fellowship at the University of Texas in Galveston, he
completed his Internal Medicine and Cardiology training at Yale
University and the University of Minnesota.
Selected committees/editorial boards:
- Associate Editor of Pharmacology & Therapeutics
- Editorial Board Member, The Canadian Journal of Cardiology
- Editorial Board Member, Open Pharmacology Journal
- Abstract Review Committee: American Heart Association
- External Scientific Expert Reviewer, Michael Smith Foundation for Health Research
- Grant Review Committee, Cardiovascular System “C”, CIHR
- Grant Review Committee 4b: Canadian Heart and Stroke Foundation
- Grant Review Committee: Research Council of Norway
- Program Committee, Cardiopulmonary and Critical Care Council, American Heart Association
- Research Committee, Department of Medicine, University of Alberta
- Scientific Advisory Board, International Academy of Cardiology.
His patents include “A Method of Treating Cancer using Dichloroacetate” and “Augmentation of K+ channel expression using adenoviral vectors”. He is a Fellow of the American Heart Association (FAHA) and a Fellow of the American College of Cardiology (FACC). Watch his CNN interview and Global Edmonton News interview. Read coverage of his work in Newsweek, NewScientist, and the Economist.