Dr. Domenico Praticó
Domenico Praticó, M.D. is
Associate Professor, Pharmacology, Temple University School of
Domenico’s research area is clinical pharmacology with a special focus on the cellular and molecular aspects of cell oxidative biology and a particular interest in small molecules such as bioactive oxidized lipids.
This area is very broad and extends to multiple disciplines including aging, cardiovascular diseases, as well as neurodegeneration. His work in the biology of oxidized bioactive lipids has significantly contributed to the current understanding of their importance as biomarkers, mediators of cellular and molecular events involved in the pathogenesis of several clinical conditions, and therapeutic targets for preventing and treating human diseases.
In his lab he employs cellular and animal models of human diseases, and in this context particular emphasis is given to the translation of any observation made in these systems into a better understanding of human physiology and pathology. He is committed to foster collaborative scientific research of the highest quality, and at the same time to provide outstanding teaching and mentoring for young scientists.
Domenico coauthored Increased Lipid Peroxidation Precedes Amyloid Plaque Formation in an Animal Model of Alzheimer Amyloidosis, Increased Formation of Distinct F2 Isoprostanes in Hypercholesterolemia, Increased F2-isoprostanes in Alzheimer’s disease: evidence for enhanced lipid peroxidation in vivo, Chronic Obstructive Pulmonary Disease Is Associated with an Increase in Urinary Levels of Isoprostane F2α-III, an Index of Oxidant Stress, Effect of Low-Dose Aspirin on Vascular Inflammation, Plaque Stability, and Atherogenesis in Low-Density Lipoprotein Receptor-Deficient Mice, and Early Vitamin E supplementation in young but not aged mice reduces Aβ levels and amyloid deposition in a transgenic model of Alzheimer’s disease.
Domenico earned his M.D. at the University of Rome “La Sapienza”, Rome, Italy in 1986.
Read Diet High in Methionine Could Increase Risk of Alzheimer’s, Can an Aspirin a Day Keep Atherosclerosis at Bay?, Nicotine May Accelerate Atherosclerosis, May Be As Dangerous As Tar, Urine Test Predicts Alzheimer’s Disease, and Penn Study Findings Reverse Key Chronology for Development of Alzheimer’s Disease.