{"id":99408,"date":"2019-12-06T21:02:43","date_gmt":"2019-12-07T05:02:43","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2019\/12\/new-tool-for-rapidly-analyzing-crispr-edits-reveals-frequent-production-of-unintended-edits"},"modified":"2019-12-06T21:02:43","modified_gmt":"2019-12-07T05:02:43","slug":"new-tool-for-rapidly-analyzing-crispr-edits-reveals-frequent-production-of-unintended-edits","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2019\/12\/new-tool-for-rapidly-analyzing-crispr-edits-reveals-frequent-production-of-unintended-edits","title":{"rendered":"New tool for rapidly analyzing CRISPR edits reveals frequent production of unintended edits"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/new-tool-for-rapidly-analyzing-crispr-edits-reveals-frequent-production-of-unintended-edits2.jpg\"><\/a><\/p>\n<p>Amidst rising hopes for using CRISPR gene editing tools to repair deadly mutations linked to conditions like cystic fibrosis and sickle cell disease, a study in <i>Communications Biology<\/i> describes a new innovation that could accelerate this work by rapidly revealing unintended and potentially harmful changes introduced by a gene editing process.<\/p>\n<p>\u201cWe\u2019ve developed a new process for rapidly screening all of the edits made by CRISPR, and it shows there may be many more unintended changes to DNA around the site of a CRISPR repair than previously thought,\u201d said Eric Kmiec, Ph.D., director of ChristianaCare\u2019s Gene Editing Institute and the principle author of the study.<\/p>\n<p>The study describes a new tool developed at the Gene Editing Institute that in just 48 hours can identify \u201cmultiple outcomes of CRISPR-directed gene editing,\u201d a process that typically required up to two months of costly and complicated DNA analysis.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Amidst rising hopes for using CRISPR gene editing tools to repair deadly mutations linked to conditions like cystic fibrosis and sickle cell disease, a study in Communications Biology describes a new innovation that could accelerate this work by rapidly revealing unintended and potentially harmful changes introduced by a gene editing process. \u201cWe\u2019ve developed a new [\u2026]<\/p>\n","protected":false},"author":396,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1902,11,412],"tags":[],"class_list":["post-99408","post","type-post","status-publish","format-standard","hentry","category-bioengineering","category-biotech-medical","category-genetics"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/99408","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/396"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=99408"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/99408\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=99408"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=99408"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=99408"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}