{"id":96667,"date":"2019-09-25T14:23:02","date_gmt":"2019-09-25T21:23:02","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2019\/09\/cellular-senescence-is-associated-with-age-related-blood-clots"},"modified":"2019-09-25T14:23:02","modified_gmt":"2019-09-25T21:23:02","slug":"cellular-senescence-is-associated-with-age-related-blood-clots","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2019\/09\/cellular-senescence-is-associated-with-age-related-blood-clots","title":{"rendered":"Cellular senescence is associated with age-related blood clots"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/cellular-senescence-is-associated-with-age-related-blood-clots.jpg\"><\/a><\/p>\n<p>Cells that become senescent irrevocably stop dividing under stress, spewing out a mix of inflammatory proteins that lead to chronic inflammation as more and more of the cells accumulate over time. <a href=\"https:\/\/www.cell.com\/cell-reports\/fulltext\/S2211-1247(19)31097-6\" target=\"_blank\" rel=\"noopener noreferrer\">Publishing in the September 24 edition of<\/a> <em>Cell Reports, <\/em>researchers at the Buck Institute identified 44 specific senescence-associated proteins that are involved in blood clotting, marking the first time that cellular senescence has been associated with age-related blood clots.<\/p>\n<p>\u201cThe incidence of venous thrombosis, which includes deep vein thrombosis and pulmonary embolism is extremely low until the age of 45, when it begins to rise rapidly. Over time it becomes a major risk factor for death. By 80, the condition affects five to six people per thousand individuals,\u201d said Judith Campisi, PhD, Buck professor and senior co-author of the study. \u201cBlood clots are also a serious side effect of chemotherapy, which sets off a cascade of senescence in those undergoing treatment. That\u2019s why blood thinners, which carry their own risks, are often included in treatment protocols.\u201d<\/p>\n<p>Scientists in the Campisi lab and other labs around the world are working to develop senolytics, drugs which would clear senescent cells from the body, potentially providing treatment options for many age-related diseases that are either caused or linked to senescence. They include Alzheimer\u2019s and Parkinson\u2019s diseases, cardiovascular disease, osteoarthritis, macular degeneration, age-related cancers and sarcopenia, among others.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Cells that become senescent irrevocably stop dividing under stress, spewing out a mix of inflammatory proteins that lead to chronic inflammation as more and more of the cells accumulate over time. Publishing in the September 24 edition of Cell Reports, researchers at the Buck Institute identified 44 specific senescence-associated proteins that are involved in blood [\u2026]<\/p>\n","protected":false},"author":511,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,269,47],"tags":[],"class_list":["post-96667","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-life-extension","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/96667","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/511"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=96667"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/96667\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=96667"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=96667"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=96667"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}