{"id":96666,"date":"2019-09-25T14:02:54","date_gmt":"2019-09-25T21:02:54","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2019\/09\/rejuvenation-in-this-issue-of-cell-baar-et-al"},"modified":"2019-09-25T14:02:54","modified_gmt":"2019-09-25T21:02:54","slug":"rejuvenation-in-this-issue-of-cell-baar-et-al","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2019\/09\/rejuvenation-in-this-issue-of-cell-baar-et-al","title":{"rendered":"Rejuvenation: In this issue of Cell, Baar et al"},"content":{"rendered":"<p><a class=\"blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/rejuvenation2.jpg\"><\/a><\/p>\n<p>In this issue of <em>Cell<\/em>, Baar et al. show how <a href=\"https:\/\/www.sciencedirect.com\/topics\/biochemistry-genetics-and-molecular-biology\/foxo4\" title=\"Learn more about FOXO4 from ScienceDirect's AI-generated Topic Pages\">FOXO4<\/a> protects senescent <a href=\"https:\/\/www.sciencedirect.com\/topics\/immunology-and-microbiology\/cell-viability\" title=\"Learn more about Cell Viability from ScienceDirect's AI-generated Topic Pages\">cell viability<\/a> by keeping <a href=\"https:\/\/www.sciencedirect.com\/topics\/immunology-and-microbiology\/p53\" title=\"Learn more about P53 from ScienceDirect's AI-generated Topic Pages\">p53<\/a> sequestered in nuclear bodies, preventing it from inducing <a href=\"https:\/\/www.sciencedirect.com\/topics\/immunology-and-microbiology\/apoptosis\" title=\"Learn more about Apoptosis from ScienceDirect's AI-generated Topic Pages\">apoptosis<\/a>. Disrupting this interaction with an all-D amino acid peptide (FOXO4-DRI) restores p53\u2019s apoptotic role and ameliorates the consequences of senescence-associated loss of tissue <a href=\"https:\/\/www.sciencedirect.com\/topics\/immunology-and-microbiology\/homeostasis\" title=\"Learn more about Homeostasis from ScienceDirect's AI-generated Topic Pages\">homeostasis<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>In this issue of Cell, Baar et al. show how FOXO4 protects senescent cell viability by keeping p53 sequestered in nuclear bodies, preventing it from inducing apoptosis. Disrupting this interaction with an all-D amino acid peptide (FOXO4-DRI) restores p53\u2019s apoptotic role and ameliorates the consequences of senescence-associated loss of tissue homeostasis.<\/p>\n","protected":false},"author":511,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[269],"tags":[],"class_list":["post-96666","post","type-post","status-publish","format-standard","hentry","category-life-extension"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/96666","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/511"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=96666"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/96666\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=96666"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=96666"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=96666"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}