{"id":96400,"date":"2019-09-18T17:43:11","date_gmt":"2019-09-19T00:43:11","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2019\/09\/study-points-to-new-drug-target-in-fight-against-cancer"},"modified":"2019-09-18T17:43:11","modified_gmt":"2019-09-19T00:43:11","slug":"study-points-to-new-drug-target-in-fight-against-cancer","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2019\/09\/study-points-to-new-drug-target-in-fight-against-cancer","title":{"rendered":"Study points to new drug target in fight against cancer"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/study-points-to-new-drug-target-in-fight-against-cancer3.jpg\"><\/a><\/p>\n<p>In a study this week in the <i>Proceedings of the National Academy of Sciences<\/i>, an international team of researchers describe how a cancer-linked version of the protein mitoNEET can close the primary gateways in the outer surface of mitochondria, the \u201cpower plants\u201d that supply <a href=\"https:\/\/medicalxpress.com\/tags\/cells\/\" rel=\"tag\" class=\"\">cells<\/a> with chemical energy. These gateways, or \u201cvoltage-dependent anion channels\u201d (VDACs), normally open and close to allow the passage of metabolites and other small molecules between mitochondria and the rest of the cell.<\/p>\n<p>\u201cThe VDAC channel transports all types of metabolites between the cytosol and the mitochondria,\u201d said study co-author Jos\u00e9 Onuchic, a physicist and co-director of Rice University\u2019s Center for Theoretical Biological Physics (CTBP). \u201cDysfunction of this channel is involved in many diseases including cancer and <a href=\"https:\/\/medicalxpress.com\/tags\/fatty+liver+disease\/\" rel=\"tag\" class=\"\">fatty liver disease<\/a>.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p>In a study this week in the Proceedings of the National Academy of Sciences, an international team of researchers describe how a cancer-linked version of the protein mitoNEET can close the primary gateways in the outer surface of mitochondria, the \u201cpower plants\u201d that supply cells with chemical energy. These gateways, or \u201cvoltage-dependent anion channels\u201d (VDACs), [\u2026]<\/p>\n","protected":false},"author":534,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-96400","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/96400","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/534"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=96400"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/96400\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=96400"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=96400"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=96400"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}