{"id":95597,"date":"2019-08-30T18:10:00","date_gmt":"2019-08-31T01:10:00","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2019\/08\/blue-brain-finds-how-neurons-in-the-mouse-neocortex-form-billions-of-synaptic-connections"},"modified":"2019-08-30T18:10:00","modified_gmt":"2019-08-31T01:10:00","slug":"blue-brain-finds-how-neurons-in-the-mouse-neocortex-form-billions-of-synaptic-connections","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2019\/08\/blue-brain-finds-how-neurons-in-the-mouse-neocortex-form-billions-of-synaptic-connections","title":{"rendered":"Blue Brain finds how neurons in the mouse neocortex form billions of synaptic connections"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/blue-brain-finds-how-neurons-in-the-mouse-neocortex-form-billions-of-synaptic-connections2.jpg\"><\/a><\/p>\n<p>Researchers at EPFL\u2019s Blue Brain Project, a Swiss brain research Initiative, have combined two high profile, large-scale datasets to produce something completely new\u2014a first draft model of the rules guiding neuron-to-neuron connectivity of a whole mouse neocortex. They generated statistical instances of the micro-connectome of 10 million neurons, a model spanning five orders of magnitude and containing 88 billion synaptic connections. A basis for the world\u2019s largest-scale simulations of detailed neural circuits.<\/p>\n<p><b>Identifying the connections across all neurons in every region of the neocortex<\/b><\/p>\n<p>The structure of synaptic connections between <a href=\"https:\/\/medicalxpress.com\/tags\/neurons\/\" rel=\"tag\" class=\"\">neurons<\/a> shapes their activity and function. Measuring a comprehensive snapshot of this so-called connectome has so far only been accomplished within tiny volumes, smaller than the head of a pin. For larger volumes, the long-range connectivity, formed by bundles of extremely thin but long fibers, has only been studied for small numbers of individual neurons, which is far from a complete picture. Alternatively, it has been studied at the macro-scale, a \u2018zoomed-out\u2019 view of average features that does not provide single-cell resolution.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers at EPFL\u2019s Blue Brain Project, a Swiss brain research Initiative, have combined two high profile, large-scale datasets to produce something completely new\u2014a first draft model of the rules guiding neuron-to-neuron connectivity of a whole mouse neocortex. They generated statistical instances of the micro-connectome of 10 million neurons, a model spanning five orders of magnitude [\u2026]<\/p>\n","protected":false},"author":511,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[47],"tags":[],"class_list":["post-95597","post","type-post","status-publish","format-standard","hentry","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/95597","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/511"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=95597"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/95597\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=95597"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=95597"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=95597"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}