{"id":95467,"date":"2019-08-28T15:23:07","date_gmt":"2019-08-28T22:23:07","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2019\/08\/nano-immunotherapy-halts-glioblastoma-in-mice"},"modified":"2019-08-28T15:23:07","modified_gmt":"2019-08-28T22:23:07","slug":"nano-immunotherapy-halts-glioblastoma-in-mice","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2019\/08\/nano-immunotherapy-halts-glioblastoma-in-mice","title":{"rendered":"\u2018Nano-immunotherapy\u2019 halts glioblastoma in mice"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/nano-immunotherapy-halts-glioblastoma-in-mice2.jpg\"><\/a><\/p>\n<p>One of the most difficult challenges in treating the brain cancer glioblastoma is that few drugs can pass through the blood-brain barrier. Scientists at Cedars-Sinai in Los Angeles have developed a system to circumvent this hurdle\u2014one that combines a powerful immuno-oncology drug with a polymer-based delivery vehicle that can cross the blood-brain barrier.<\/p>\n<p>The researchers showed that this \u201cnano-immunotherapy\u201d treatment crossed the blood-brain barrier in mouse models of glioblastoma, and that it stopped tumor cells from multiplying. They published their <a href=\"https:\/\/www.nature.com\/articles\/s41467-019-11719-3\">findings<\/a> in the journal Nature Communications.<\/p>\n<p>The Cedars-Sinai team used the polymer scaffold to deliver two types of immune checkpoint inhibitors, blocking either CTLA-4 or PD-1. When injected into the bloodstream of mice, the drugs quickly infiltrated brain tumors, but not healthy brain tissue, the researchers reported.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>One of the most difficult challenges in treating the brain cancer glioblastoma is that few drugs can pass through the blood-brain barrier. Scientists at Cedars-Sinai in Los Angeles have developed a system to circumvent this hurdle\u2014one that combines a powerful immuno-oncology drug with a polymer-based delivery vehicle that can cross the blood-brain barrier. The researchers [\u2026]<\/p>\n","protected":false},"author":395,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,4,6],"tags":[],"class_list":["post-95467","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-nanotechnology","category-robotics-ai"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/95467","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/395"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=95467"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/95467\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=95467"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=95467"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=95467"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}