{"id":95242,"date":"2019-08-24T21:23:20","date_gmt":"2019-08-25T04:23:20","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2019\/08\/researchers-advance-organ-on-chip-technology-to-advance-drug-development"},"modified":"2019-08-24T21:23:20","modified_gmt":"2019-08-25T04:23:20","slug":"researchers-advance-organ-on-chip-technology-to-advance-drug-development","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2019\/08\/researchers-advance-organ-on-chip-technology-to-advance-drug-development","title":{"rendered":"Researchers advance organ-on-chip technology to advance drug development"},"content":{"rendered":"<p><\/p>\n<p><iframe style=\"display: block; margin: 0 auto; width: 100%; aspect-ratio: 4\/3; object-fit: contain;\" src=\"https:\/\/www.youtube.com\/embed\/D8reU-dKOrA?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; encrypted-media; gyroscope;\n   picture-in-picture\" allowfullscreen><\/iframe><\/p>\n<p>Researchers from Carnegie Mellon University (CMU) and Nanyang Technological University, Singapore (NTU Singapore) have developed an organ-on-an-electronic-chip platform, which uses bioelectrical sensors to measure the electrophysiology of the heart cells in three dimensions. These 3D, self-rolling biosensor arrays coil up over heart cell spheroid tissues to form an \u201corgan-on-e-chip,\u201d thus enabling the researchers to study how cells communicate with each other in multicellular systems such as the heart.<\/p>\n<p>The organ-on-e-chip approach will help develop and assess the efficacy of drugs for disease treatment\u2014perhaps even enabling researchers to screen for drugs and toxins directly on a human-like <a href=\"https:\/\/techxplore.com\/tags\/tissue\/\" rel=\"tag\" class=\"\">tissue<\/a>, rather than testing on animal tissue. The platform will also be used to shed light on the connection between the heart\u2019s <a href=\"https:\/\/techxplore.com\/tags\/electrical+signals\/\" rel=\"tag\" class=\"\">electrical signals<\/a> and disease, such as arrhythmias. The research, published in <i>Science Advances<\/i>, allows the researchers to investigate processes in cultured cells that currently are not accessible, such as tissue development and cell maturation.<\/p>\n<p>\u201cFor decades, electrophysiology was done using cells and cultures on two-dimensional surfaces, such as culture dishes,\u201d says Associate Professor of Biomedical Engineering (BME) and Materials Science &amp; Engineering (MSE) Tzahi Cohen-Karni. \u201cWe are trying to circumvent the challenge of reading the heart\u2019s electrical patterns in 3D by developing a way to shrink-wrap sensors around heart cells and extracting electrophysiological information from this tissue.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers from Carnegie Mellon University (CMU) and Nanyang Technological University, Singapore (NTU Singapore) have developed an organ-on-an-electronic-chip platform, which uses bioelectrical sensors to measure the electrophysiology of the heart cells in three dimensions. These 3D, self-rolling biosensor arrays coil up over heart cell spheroid tissues to form an \u201corgan-on-e-chip,\u201d thus enabling the researchers to study [\u2026]<\/p>\n","protected":false},"author":427,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,1523,38],"tags":[],"class_list":["post-95242","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-computing","category-engineering"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/95242","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/427"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=95242"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/95242\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=95242"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=95242"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=95242"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}