{"id":94862,"date":"2019-08-16T11:22:27","date_gmt":"2019-08-16T18:22:27","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2019\/08\/tweaked-crispr-in-neurons-gives-scientists-new-power-to-probe-brain-diseases"},"modified":"2019-08-16T11:22:27","modified_gmt":"2019-08-16T18:22:27","slug":"tweaked-crispr-in-neurons-gives-scientists-new-power-to-probe-brain-diseases","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2019\/08\/tweaked-crispr-in-neurons-gives-scientists-new-power-to-probe-brain-diseases","title":{"rendered":"Tweaked CRISPR in neurons gives scientists new power to probe brain diseases"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/tweaked-crispr-in-neurons-gives-scientists-new-power-to-probe-brain-diseases2.jpg\"><\/a><\/p>\n<p>A team of scientists at UC San Francisco and the National Institutes of Health have achieved another CRISPR first, one which may fundamentally alter the way scientists study brain diseases.<\/p>\n<p>In a paper published August 15 in the journal <i>Neuron<\/i>, the researchers describe a technique that uses a special version of CRISPR developed at UCSF to systematically alter the activity of <a href=\"https:\/\/medicalxpress.com\/tags\/genes\/\" rel=\"tag\" class=\"\">genes<\/a> in human neurons generated from <a href=\"https:\/\/medicalxpress.com\/tags\/stem+cells\/\" rel=\"tag\" class=\"\">stem cells<\/a>, the first successful merger of stem cell-derived cell types and CRISPR screening technologies.<\/p>\n<p>Though mutations and other genetic variants are known to be associated with an increased risk for many <a href=\"https:\/\/medicalxpress.com\/tags\/neurological+diseases\/\" rel=\"tag\" class=\"\">neurological diseases<\/a>, technological bottlenecks have thwarted the efforts of scientists working to understand exactly how these genes cause <a href=\"https:\/\/medicalxpress.com\/tags\/disease\/\" rel=\"tag\" class=\"\">disease<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A team of scientists at UC San Francisco and the National Institutes of Health have achieved another CRISPR first, one which may fundamentally alter the way scientists study brain diseases. In a paper published August 15 in the journal Neuron, the researchers describe a technique that uses a special version of CRISPR developed at UCSF [\u2026]<\/p>\n","protected":false},"author":396,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412,1495,47],"tags":[],"class_list":["post-94862","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics","category-health","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/94862","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/396"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=94862"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/94862\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=94862"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=94862"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=94862"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}