{"id":94763,"date":"2019-08-14T11:22:31","date_gmt":"2019-08-14T18:22:31","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2019\/08\/how-a-one-time-crispr-shot-could-obliterate-lower-back-pain"},"modified":"2019-08-14T11:22:31","modified_gmt":"2019-08-14T18:22:31","slug":"how-a-one-time-crispr-shot-could-obliterate-lower-back-pain","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2019\/08\/how-a-one-time-crispr-shot-could-obliterate-lower-back-pain","title":{"rendered":"How a one-time CRISPR shot could obliterate lower back pain"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/how-a-one-time-crispr-shot-could-obliterate-lower-back-pain.jpg\"><\/a><\/p>\n<p>Today [August 13] the US National Academy of Sciences is hosting the first meeting of the <a href=\"http:\/\/nationalacademies.org\/gene-editing\/international-commission\/index.htm\" data-wpel-link=\"external\" target=\"_blank\" rel=\"nofollow external noopener noreferrer\">International Commission on the Clinical Use of Human Germline Genome Editing<\/a> in Washington, to discuss controversial applications of CRISPR to human eggs, sperm, or fertilized ova, in the wake of Chinese researcher He Jiankui announcing the birth of CRISPR twins after a similar meeting in 2017 (See <a href=\"https:\/\/geneticliteracyproject.org\/2019\/06\/11\/do-chinas-controversial-crispr-babies-illustrate-the-need-for-an-undo-button\/\" data-wpel-link=\"internal\">Do China\u2019s controversial CRISPR babies illustrate the need for an undo button?)<\/a><\/p>\n<p>Although only <a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03745287\" data-wpel-link=\"external\" target=\"_blank\" rel=\"nofollow external noopener noreferrer\">one clinical trial<\/a> is up-and-running for CRISPR to treat <em>body<\/em> cells, with an initial patient making the media rounds <a href=\"https:\/\/www.popsci.com\/crispr-gene-editing-treatment-sickle-cell-anemia\/\" data-wpel-link=\"external\" target=\"_blank\" rel=\"nofollow external noopener noreferrer\">just last week<\/a> to discuss her cells doctored to counter sickle cell disease, many other applications are in preclinical testing \u2014 animal models and human cells and organoids. And they\u2019re not restricted to rare diseases.<\/p>\n<p>Imagine a single injection that quells the inflammation behind lower back pain \u2014 perhaps forever. CRISPR may make that possible by dampening the immune system\u2019s cytokine signals, according to a report in the July issue of <em><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31140325\" data-wpel-link=\"external\" target=\"_blank\" rel=\"nofollow external noopener noreferrer\">Human Gene Therapy<\/a><\/em>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Today [August 13] the US National Academy of Sciences is hosting the first meeting of the International Commission on the Clinical Use of Human Germline Genome Editing in Washington, to discuss controversial applications of CRISPR to human eggs, sperm, or fertilized ova, in the wake of Chinese researcher He Jiankui announcing the birth of CRISPR [\u2026]<\/p>\n","protected":false},"author":396,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-94763","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/94763","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/396"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=94763"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/94763\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=94763"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=94763"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=94763"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}