{"id":94370,"date":"2019-08-02T09:23:00","date_gmt":"2019-08-02T16:23:00","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2019\/08\/targeting-a-blood-stem-cell-subset-shows-lasting-therapeutically-relevant-gene-editing"},"modified":"2019-08-02T09:23:00","modified_gmt":"2019-08-02T16:23:00","slug":"targeting-a-blood-stem-cell-subset-shows-lasting-therapeutically-relevant-gene-editing","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2019\/08\/targeting-a-blood-stem-cell-subset-shows-lasting-therapeutically-relevant-gene-editing","title":{"rendered":"Targeting a blood stem cell subset shows lasting, therapeutically relevant gene editing"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/targeting-a-blood-stem-cell-subset-shows-lasting-therapeutically-relevant-gene-editing2.jpg\"><\/a><\/p>\n<p>In a paper published in the July 31 issue of <em>Science Translational Medicine<\/em>, researchers at Fred Hutchinson Cancer Research Center used CRISPR-Cas9 to edit long-lived blood stem cells to reverse the clinical symptoms observed with several blood disorders, including sickle cell disease and beta-thalassemia.<\/p>\n<p>It\u2019s the first time that scientists have specifically edited the genetic makeup of a specialized subset of adult blood stem cells that are the source of all cells in the blood and immune system.<\/p>\n<p>The proof-of-principle study suggests that efficient modification of targeted stem cells could reduce the costs of gene-editing treatments for blood disorders and other diseases while decreasing the risks of unwanted effects that can occur with a less discriminating approach.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>In a paper published in the July 31 issue of Science Translational Medicine, researchers at Fred Hutchinson Cancer Research Center used CRISPR-Cas9 to edit long-lived blood stem cells to reverse the clinical symptoms observed with several blood disorders, including sickle cell disease and beta-thalassemia. It\u2019s the first time that scientists have specifically edited the genetic [\u2026]<\/p>\n","protected":false},"author":396,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1902,11,412],"tags":[],"class_list":["post-94370","post","type-post","status-publish","format-standard","hentry","category-bioengineering","category-biotech-medical","category-genetics"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/94370","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/396"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=94370"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/94370\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=94370"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=94370"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=94370"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}