{"id":94258,"date":"2019-07-30T11:42:38","date_gmt":"2019-07-30T18:42:38","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2019\/07\/senolytics-show-promise-against-alzheimers-in-mice"},"modified":"2019-07-30T11:42:38","modified_gmt":"2019-07-30T18:42:38","slug":"senolytics-show-promise-against-alzheimers-in-mice","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2019\/07\/senolytics-show-promise-against-alzheimers-in-mice","title":{"rendered":"Senolytics Show Promise Against Alzheimer\u2019s in Mice"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/senolytics-show-promise-against-alzheimers-in-mice2.jpg\"><\/a><\/p>\n<p>For the past quarter century, scientists battled Alzheimer\u2019s disease under <a href=\"https:\/\/www.theatlantic.com\/health\/archive\/2017\/02\/alzheimers-amyloid-hypothesis\/517185\/\">a single guiding principle<\/a>: that protein clumps\u2014beta-amyloid\u2014deposited outside sensitive brain cells gradually damage neuronal functions and trigger memory loss. The solution seems simple: remove junk amyloid, protect the brain.<\/p>\n<p>They could be completely wrong.<\/p>\n<p>Last month, Alzheimer\u2019s disease <a href=\"https:\/\/www.statnews.com\/2019\/03\/21\/biogen-eisai-alzheimer-trial-stopped\/\">defeated another promising<\/a> near-market drug that tried to prevent or remove amyloid deposits, adding to the disease\u2019s therapeutic \u201c<a href=\"https:\/\/singularityhub.com\/2019\/01\/17\/5-discoveries-that-made-2018-a-huge-year-for-neuroscience\/\">graveyard of dreams<\/a>.\u201d Although the drug removed toxic amyloid, the patients <a href=\"https:\/\/www.statnews.com\/2019\/04\/01\/alzheimers-patients-coping-with-treatments-failure\/\">didn\u2019t get better<\/a>. The failure is once again spurring scientists to confront an uncomfortable truth: targeting amyloid clumps when patients already show memory symptoms doesn\u2019t work. Wiping out soluble amyloid\u2014fragments of proteins before they aggregate into junk\u2014also dead ends.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>For the past quarter century, scientists battled Alzheimer\u2019s disease under a single guiding principle: that protein clumps\u2014beta-amyloid\u2014deposited outside sensitive brain cells gradually damage neuronal functions and trigger memory loss. The solution seems simple: remove junk amyloid, protect the brain. They could be completely wrong. Last month, Alzheimer\u2019s disease defeated another promising near-market drug that tried [\u2026]<\/p>\n","protected":false},"author":367,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,47],"tags":[],"class_list":["post-94258","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/94258","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/367"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=94258"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/94258\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=94258"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=94258"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=94258"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}