{"id":94215,"date":"2019-07-29T07:09:11","date_gmt":"2019-07-29T14:09:11","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2019\/07\/new-method-of-halting-%ce%b1-synuclein-aggregation"},"modified":"2019-07-29T07:09:11","modified_gmt":"2019-07-29T14:09:11","slug":"new-method-of-halting-%ce%b1-synuclein-aggregation","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2019\/07\/new-method-of-halting-%ce%b1-synuclein-aggregation","title":{"rendered":"New Method of Halting \u03b1-Synuclein Aggregation"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/new-method-of-halting-ceb1-synuclein-aggregation.jpg\"><\/a><\/p>\n<p>Researchers from the Beijing Institute of Brain Disorders have discovered <a href=\"https:\/\/www.cell.com\/molecular-therapy-family\/nucleic-acids\/fulltext\/S2162-2531%2819%2930198-2\" target=\"_blank\" rel=\"noopener\">a new method<\/a> of using exosomes to deliver aptamers that prevent the accumulation of \u03b1-synuclein aggregates, which are the cause of Parkinson\u2019s disease [1].<\/p>\n<p><strong>\u03b1-Synuclein Aggregates<\/strong><\/p>\n<p>Like Alzheimer\u2019s, Parkinson\u2019s disease is characterized by protein aggregation caused by a <a href=\"https:\/\/www.leafscience.org\/aging-loss-of-proteostasis\/\">loss of proteostasis<\/a>, one of the hallmarks of aging. In order for the brain to function properly, non-aggregated \u03b1-synuclein proteins are needed in order to facilitate the release of dopamine, a neurotransmitter, in nerve cell synapses. \u03b1-synuclein only becomes a problem when proteostasis fails and the proteins misfold, aggregate, and accumulate.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers from the Beijing Institute of Brain Disorders have discovered a new method of using exosomes to deliver aptamers that prevent the accumulation of \u03b1-synuclein aggregates, which are the cause of Parkinson\u2019s disease [1]. \u03b1-Synuclein Aggregates Like Alzheimer\u2019s, Parkinson\u2019s disease is characterized by protein aggregation caused by a loss of proteostasis, one of the hallmarks [\u2026]<\/p>\n","protected":false},"author":370,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,269,47],"tags":[],"class_list":["post-94215","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-life-extension","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/94215","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/370"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=94215"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/94215\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=94215"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=94215"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=94215"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}