{"id":94,"date":"2007-09-27T09:56:41","date_gmt":"2007-09-27T16:56:41","guid":{"rendered":"http:\/\/lifeboat.com\/blog\/?p=94"},"modified":"2017-04-25T04:51:17","modified_gmt":"2017-04-25T11:51:17","slug":"new-field-deployable-biosensor-detects-avian-influenza-virus-in-minutes-instead-of-days","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2007\/09\/new-field-deployable-biosensor-detects-avian-influenza-virus-in-minutes-instead-of-days","title":{"rendered":"New field-deployable biosensor detects avian influenza virus in minutes instead of days"},"content":{"rendered":"<p><a href=\"http:\/\/www.physorg.com\/news110115421.html\">A new biosensor developed at the Georgia Tech Research Institute (GTRI) can detect avian influenza in just minutes.<\/a> In addition to being a rapid test, the biosensor is economical, field-deployable, sensitive to different viral strains and requires no labels or reagents. <\/p>\n<p>This kind of technology could be applied to real time monitoring of other diseases as well.<\/p>\n<p><img decoding=\"async\" src=\"\"><br \/> Photograph of the optical biosensor that is approximately 16 millimeters by 33 millimeters in size. The horizontal purple lines are the channels on the waveguide. Credit: Gary Meek<\/p>\n<blockquote><p>\u201cWe can do real-time monitoring of avian influenza infections on the farm, in live-bird markets or in poultry processing facilities,\u201d said Jie Xu, a research scientist in GTRI\u2019s Electro-Optical Systems Laboratory (EOSL) <\/p>\n<p>The biosensor is coated with antibodies specifically designed to capture a protein located on the surface of the viral particle. For this study, the researchers evaluated the sensitivity of three unique antibodies to detect avian influenza virus. <\/p>\n<p>The sensor utilizes the interference of light waves, a concept called interferometry, to precisely determine how many virus particles attach to the sensor\u2019s surface. More specifically, light from a laser diode is coupled into an optical waveguide through a grating and travels under one sensing channel and one reference channel. <\/p>\n<p>Researchers coat the sensing channel with the specific antibodies and coat the reference channel with non-specific antibodies. Having the reference channel minimizes the impact of non-specific interactions, as well as changes in temperature, pH and mechanical motion. Non-specific binding should occur equally to both the test and reference channels and thus not affect the test results. <\/p>\n<p>An electromagnetic field associated with the light beams extends above the waveguides and is very sensitive to the changes caused by antibody-antigen interactions on the waveguide surface. When a liquid sample passes over the waveguides, any binding that occurs on the top of a waveguide because of viral particle attachment causes water molecules to be displaced. This causes a change in the velocity of the light traveling through the waveguide. <\/p><\/blockquote>\n","protected":false},"excerpt":{"rendered":"<p>A new biosensor developed at the Georgia Tech Research Institute (GTRI) can detect avian influenza in just minutes. In addition to being a rapid test, the biosensor is economical, field-deployable, sensitive to different viral strains and requires no labels or reagents. This kind of technology could be applied to real time monitoring of other diseases [\u2026]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3,14,7],"tags":[],"class_list":["post-94","post","type-post","status-publish","format-standard","hentry","category-biological","category-defense","category-lifeboat"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/94","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=94"}],"version-history":[{"count":1,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/94\/revisions"}],"predecessor-version":[{"id":52296,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/94\/revisions\/52296"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=94"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=94"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=94"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}