{"id":93010,"date":"2019-07-02T09:42:50","date_gmt":"2019-07-02T16:42:50","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2019\/07\/21cm-cryopreservation-eval-page-foundation"},"modified":"2019-07-02T09:42:50","modified_gmt":"2019-07-02T16:42:50","slug":"21cm-cryopreservation-eval-page-foundation","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2019\/07\/21cm-cryopreservation-eval-page-foundation","title":{"rendered":"21CM Cryopreservation Eval Page Foundation"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/21cm-cryopreservation-eval-page-foundation.jpg\"><\/a><\/p>\n<p style=\"padding-right: 20px\"><a class=\\'blog-photo\\' href=\"https:\/\/lifeboat.com\/blog.images\/21cm-cryopreservation-eval-page-foundation3.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter\" class=\"alignleft\" src=\"https:\/\/lifeboat.com\/blog.images\/21cm-cryopreservation-eval-page-foundation3.jpg\" alt=\"Pichugin2006_Fahy2012_FrontPageImagesRotated\" width=\"408\" height=\"538\" srcset=\"http:\/\/www.brainpreservation.org\/wp-content\/uploads\/2015\/08\/Pichugin2006_Fahy2012_FrontPageImagesRotated.jpg 473w, http:\/\/www.brainpreservation.org\/wp-content\/uploads\/2015\/08\/Pichugin2006_Fahy2012_FrontPageImagesRotated-227x300.jpg 227w\" sizes=\"auto, (max-width: 408px)  100vw, 408px\" \/><\/a><\/p>\n<p> <a href=\"http:\/\/www.21cm.com\/\">21st Century Medicine<\/a> (21CM) is a cryobiology research company whose core mission is to develop a cryopreservation protocol sufficiently benign that whole, donated human organs could be vitrified (stored <a href=\"http:\/\/www.alcor.org\/Library\/html\/HowColdIsColdEnough.html\">below &minus;130 degrees Celsius<\/a> without ice formation) and rewarmed when needed for transplantation \u2013an incredibly ambitious goal that has so far eluded medical researchers. 21CM\u2019s scientists are the original pioneers of whole organ vitrification and have been diligently working on the technique for <a href=\"http:\/\/www.21cmpublications.com\/viewpublication.aspx?id=82\">decades<\/a>. A significant milestone of their progress toward that goal is their demonstration work on rabbit kidneys. Two of their most relevant publications are \u201c<a href=\"https:\/\/doi.org\/10.1016\/j.cryobiol.2004.02.002\">Cryopreservation of organs by vitrification: perspectives and recent advances<\/a>\u201d (Fahy, Wowk, Wu, Phan, Rasch, Chang &amp; Zendejas 2004) and \u201c<a href=\"http:\/\/www.21cmpublications.com\/PubFiles\/11\/12FahyORG5-3[1].pdf\">Physical and biological aspects of renal vitrification<\/a>\u201d (Fahy, Wowk, Pagotan, Chang, Phan, Thomson &amp; Phan 2009). These papers are a fantastic resource for anyone interested in just how difficult it is to cryopreserve large organs (and by extension whole animals) for long-term storage with the intent on later recovery of biological function. In short, it is incredibly difficult but progress is slowly being made.<\/p>\n<p>The state-of-the-art whole organ vitrification techniques developed by 21CM are the basis of the human cryopreservation protocols used by some cryonics companies (e.g. <a href=\"http:\/\/www.alcor.org\/\">Alcor<\/a>). This is made clear in Alcor\u2019s 2004 publication in the New York Academy of Sciences \u201c<a href=\"https:\/\/doi.org\/10.1196\/annals.1297.104\">The Arrest of Biological Time as a Bridge to Engineered Negligible Senescence<\/a>\u201d (Lemler, Harris, Platt &amp; Huffman 2004).<\/p>\n<p>21CM has been an official competitor in our Brain Preservation Prize competition since 2012. They actually have two separate preservation techniques competing for our prize: the \u201cstraight\u201d cryopreservation\\cryonics technique described on this page, and a radically new technique called \u201cAldehyde Stabilized Cryopreservation\u201d (ASC), described on a <a href=\"http:\/\/brainpreservation.org\/21cm-aldehyde-stabilized-cryopreservation-eval-page\/\">separate page<\/a>,which they developed to overcome the \u201ctissue shrinkage\u201d issues described on this page and to optimize ultrastructure preservation at the expense of viability.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>21st Century Medicine (21CM) is a cryobiology research company whose core mission is to develop a cryopreservation protocol sufficiently benign that whole, donated human organs could be vitrified (stored below \u2212130 degrees Celsius without ice formation) and rewarmed when needed for transplantation \u2013an incredibly ambitious goal that has so far eluded medical researchers. 21CM\u2019s scientists [\u2026]<\/p>\n","protected":false},"author":511,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,2017,269,47],"tags":[],"class_list":["post-93010","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-cryonics","category-life-extension","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/93010","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/511"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=93010"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/93010\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=93010"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=93010"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=93010"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}