{"id":92453,"date":"2019-06-21T13:24:37","date_gmt":"2019-06-21T20:24:37","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2019\/06\/a-new-drug-target-for-chemically-induced-parkinsons-disease"},"modified":"2019-06-21T13:24:37","modified_gmt":"2019-06-21T20:24:37","slug":"a-new-drug-target-for-chemically-induced-parkinsons-disease","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2019\/06\/a-new-drug-target-for-chemically-induced-parkinsons-disease","title":{"rendered":"A new drug target for chemically induced Parkinson\u2019s disease"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/a-new-drug-target-for-chemically-induced-parkinsons-disease2.jpg\"><\/a><\/p>\n<p>More than three decades ago, scientists discovered that a chemical found in a synthetic opioid, MPTP, induced the onset of a form of Parkinson\u2019s disease. In a new study led by scientists from the School of Veterinary Medicine, researchers found that an enzyme in the body can metabolize compounds formed in the brain from alkaloids present in certain foods and tobacco into MPTP-like chemicals, triggering a neurodegenerative condition in mice.<\/p>\n<p>The researchers, led by Narayan Avadhani and Mrittika Chattopadhyay, suggest that the enzyme, mitochondrial CYP2D6, presents a potentially powerful new target for Parkinson\u2019s treatment.<\/p>\n<p>\u201cOver the past two or three decades, researchers have tried inhibiting the process by which they believed MPTP was metabolized, with mixed success,\u201d says Avadhani. \u201cWe believe that mitochondrial CYP2D6 is the more direct drug target, which might prove better in treating idiopathic Parkinson\u2019s disease.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p>More than three decades ago, scientists discovered that a chemical found in a synthetic opioid, MPTP, induced the onset of a form of Parkinson\u2019s disease. In a new study led by scientists from the School of Veterinary Medicine, researchers found that an enzyme in the body can metabolize compounds formed in the brain from alkaloids [\u2026]<\/p>\n","protected":false},"author":511,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,1506,47],"tags":[],"class_list":["post-92453","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-food","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/92453","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/511"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=92453"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/92453\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=92453"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=92453"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=92453"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}