{"id":91997,"date":"2019-06-13T11:27:35","date_gmt":"2019-06-13T18:27:35","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2019\/06\/crispr-cas9-therapy-may-suppress-aging"},"modified":"2019-06-13T11:27:35","modified_gmt":"2019-06-13T18:27:35","slug":"crispr-cas9-therapy-may-suppress-aging","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2019\/06\/crispr-cas9-therapy-may-suppress-aging","title":{"rendered":"CRISPR-Cas9 Therapy May Suppress Aging"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/crispr-cas9-therapy-may-suppress-aging2.jpg\"><\/a><\/p>\n<p>Age is a leading risk factor for a number of conditions such as heart disease, cancer, and Alzheimer\u2019s disease among others, such conditions make a real need for development of anti-aging therapies urgent. Salk Institute researchers may have developed a new gene therapy to help decelerate the aging process, as published in the journal Nature Medicine.<\/p>\n<p>CRISPR-Cas9 genome editing therapy has been shown by the Salk Institute team to suppress the accelerated aging observed in mice with Hutchinson-Gilford Progeria syndrome; and provided insight into the molecular pathways involved in accelerated aging, and how to reduce toxic proteins via gene therapy.<\/p>\n<p>Having an early onset and fast progression progeria is a severe form of degenerative disorder caused by LMNA gene mutations; signs of accelerated aging include DNA damage, cardiac dysfunction, and dramatically shortened lifespan. LMNA genes produce lamin A and lamin C inside a cell, progeria shifts production of lamin A to progerin which is a toxic shortened form of lamin A that accumulates with age and becomes exacerbated with the condition.<\/p>\n<p><a href=\"https:\/\/worldhealth.net\/news\/crispr-cas9-therapy-may-suppress-aging\/\" target=\"_blank\" rel=\"noopener noreferrer\"><\/p>\n<div style=\"clear:both;\">Read more<\/div>\n<p><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Age is a leading risk factor for a number of conditions such as heart disease, cancer, and Alzheimer\u2019s disease among others, such conditions make a real need for development of anti-aging therapies urgent. Salk Institute researchers may have developed a new gene therapy to help decelerate the aging process, as published in the journal Nature [\u2026]<\/p>\n","protected":false},"author":513,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412,269,47],"tags":[],"class_list":["post-91997","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics","category-life-extension","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/91997","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/513"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=91997"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/91997\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=91997"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=91997"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=91997"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}