{"id":91471,"date":"2019-05-31T12:02:22","date_gmt":"2019-05-31T19:02:22","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2019\/05\/study-reveals-structure-of-a-master-switch-controlling-cell-division"},"modified":"2019-05-31T12:02:22","modified_gmt":"2019-05-31T19:02:22","slug":"study-reveals-structure-of-a-master-switch-controlling-cell-division","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2019\/05\/study-reveals-structure-of-a-master-switch-controlling-cell-division","title":{"rendered":"Study reveals structure of a \u2018master switch\u2019 controlling cell division"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/study-reveals-structure-of-a-master-switch-controlling-cell-division3.jpg\"><\/a><\/p>\n<p>Unregulated cell division is a hallmark of cancer, and one of the key proteins involved in controlling cell division is called FoxM1. Abnormal activation of FoxM1 is a common feature of cancer cells and is correlated with poor prognosis, metastasis, and resistance to chemotherapy.<\/p>\n<p>Now researchers at UC Santa Cruz have determined the structure of this protein\u2014a kind of \u201cmaster switch\u201d for cell division\u2014in its inactive or \u201coff\u201d conformation. This new understanding of the structure of FoxM1 could ultimately be used to design new drugs that stabilize the protein in its inactive state and thereby stop the uncontrolled proliferation of cancer cells.<\/p>\n<p>Seth Rubin, professor of chemistry and biochemistry at UC Santa Cruz, explained that FoxM1 is a \u201ctranscription factor,\u201d a protein that controls the activity of specific genes.<\/p>\n<p><a href=\"https:\/\/www.eurekalert.org\/pub_releases\/2019-05\/uoc--srs052819.php\" target=\"_blank\" rel=\"noopener noreferrer\"><\/p>\n<div style=\"clear:both;\">Read more<\/div>\n<p><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Unregulated cell division is a hallmark of cancer, and one of the key proteins involved in controlling cell division is called FoxM1. Abnormal activation of FoxM1 is a common feature of cancer cells and is correlated with poor prognosis, metastasis, and resistance to chemotherapy. Now researchers at UC Santa Cruz have determined the structure of [\u2026]<\/p>\n","protected":false},"author":511,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-91471","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/91471","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/511"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=91471"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/91471\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=91471"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=91471"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=91471"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}