{"id":90888,"date":"2019-05-17T13:48:13","date_gmt":"2019-05-17T20:48:13","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2019\/05\/mast-cells-crucial-to-causing-osteoarthritis"},"modified":"2019-05-17T13:48:13","modified_gmt":"2019-05-17T20:48:13","slug":"mast-cells-crucial-to-causing-osteoarthritis","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2019\/05\/mast-cells-crucial-to-causing-osteoarthritis","title":{"rendered":"Mast cells crucial to causing osteoarthritis"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/mast-cells-crucial-to-causing-osteoarthritis.jpg\"><\/a><\/p>\n<p>Stanford University School of Medicine scientists have definitively linked mast cells, a class of cells belonging to the immune system, to the development of osteoarthritis, one of the world\u2019s most common causes of pain and immobility.<\/p>\n<p>In a study published online May 14 in <i>eLife<\/i>, the scientists demonstrated for the first time that banishing <a href=\"https:\/\/medicalxpress.com\/tags\/mast\/\" rel=\"tag\" class=\"\">mast<\/a> <a href=\"https:\/\/medicalxpress.com\/tags\/cells\/\" rel=\"tag\" class=\"\">cells<\/a>\u2014or blocking signals from the most common stimulus activating them in real life, or disabling a cartilage-degrading enzyme they release when activated\u2014all protected mice from developing <a href=\"https:\/\/medicalxpress.com\/tags\/osteoarthritis\/\" rel=\"tag\" class=\"\">osteoarthritis<\/a> typically induced by a classic experimental procedure. The results were supported by findings in <a href=\"https:\/\/medicalxpress.com\/tags\/human+cells\/\" rel=\"tag\" class=\"\">human cells<\/a> and tissues.<\/p>\n<p>Osteoarthritis, by far the most frequently occurring variety of arthritis, is characterized by cartilage breakdown and inflammation in joints, which can be further aggravated by excess bone growths called osteophytes.<\/p>\n<p><a href=\"https:\/\/medicalxpress.com\/news\/2019-05-mast-cells-crucial-osteoarthritis.html\" target=\"_blank\" rel=\"noopener noreferrer\"><\/p>\n<div style=\"clear:both;\">Read more<\/div>\n<p><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Stanford University School of Medicine scientists have definitively linked mast cells, a class of cells belonging to the immune system, to the development of osteoarthritis, one of the world\u2019s most common causes of pain and immobility. In a study published online May 14 in eLife, the scientists demonstrated for the first time that banishing mast [\u2026]<\/p>\n","protected":false},"author":513,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-90888","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/90888","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/513"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=90888"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/90888\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=90888"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=90888"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=90888"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}