{"id":90852,"date":"2019-05-17T11:23:21","date_gmt":"2019-05-17T18:23:21","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2019\/05\/researchers-have-identified-the-first-human-specific-fusion-gene"},"modified":"2019-05-17T11:23:21","modified_gmt":"2019-05-17T18:23:21","slug":"researchers-have-identified-the-first-human-specific-fusion-gene","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2019\/05\/researchers-have-identified-the-first-human-specific-fusion-gene","title":{"rendered":"Researchers have identified the first human-specific fusion gene"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/researchers-have-identified-the-first-human-specific-fusion-gene2.jpg\"><\/a><\/p>\n<p>University at Buffalo researchers have identified the first human-specific fusion gene\u2014a hybrid of two genes\u2014implicated in Alzheimer\u2019s disease. The finding suggests that a neurotransmitter receptor, previously successful in animal studies but that failed in human trials for Alzheimer\u2019s, might still turn out to be a valuable therapy.<\/p>\n<p>In a paper published in February in <i>Translational Psychiatry<\/i>, the UB researchers reported that this human <a href=\"https:\/\/medicalxpress.com\/tags\/fusion\/\" rel=\"tag\" class=\"\">fusion<\/a> gene acts on a receptor for the neurotransmitter acetylcholine, which is involved in memory and learning, and which is reduced in people with Alzheimer\u2019s.<\/p>\n<p>The fusion gene is CHRFAM7A, which is very common in people and has been implicated in many <a href=\"https:\/\/medicalxpress.com\/tags\/neuropsychiatric+disorders\/\" rel=\"tag\" class=\"\">neuropsychiatric disorders<\/a>, such as schizophrenia and bipolar disease.<\/p>\n<p><a href=\"https:\/\/medicalxpress.com\/news\/2019-05-human-specific-fusion-gene.html\" target=\"_blank\" rel=\"noopener noreferrer\"><\/p>\n<div style=\"clear:both;\">Read more<\/div>\n<p><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>University at Buffalo researchers have identified the first human-specific fusion gene\u2014a hybrid of two genes\u2014implicated in Alzheimer\u2019s disease. The finding suggests that a neurotransmitter receptor, previously successful in animal studies but that failed in human trials for Alzheimer\u2019s, might still turn out to be a valuable therapy. In a paper published in February in Translational [\u2026]<\/p>\n","protected":false},"author":511,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,47],"tags":[],"class_list":["post-90852","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/90852","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/511"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=90852"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/90852\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=90852"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=90852"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=90852"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}