On senescent cells, mechanism of interaction and (potential?!) side effects of NAD+ supplements. \u201c\u2026 Those people self-experimenting with NAD+ precursor supplementation should consider keeping a close eye on markers of inflammation\u2026\u201d<\/p>\n
Enhancing levels of NAD+<\/a> in mitochondria<\/a> via delivery of various precursor compounds as supplements is growing in popularity as an approach to boost faltering mitochondrial function<\/a> and thus modestly slow the progression of aging. A human trial demonstrated improved vascular function<\/a> as a result of nicotinamide riboside supplementation<\/a>, for example. Researchers here show that increased NAD+ will likely make worse the inflammatory signaling<\/a> of senescent cells<\/a>, however. Senescent cells accumulate with age<\/a>, and are an important cause of the chronic inflammation<\/a> of aging that drives the progression of many age-related diseases.<\/p>\n The results here suggest that efficient senolytic treatments<\/a> to selectively destroy senescent cells should proceed any of the current approaches to raising levels of NAD+ in older individuals \u2014 and it is an open question as to whether any of the existing available options are efficient enough to make NAD+ enhancement safe in the longer term. Those people self-experimenting with NAD+ precursor supplementation<\/a> should consider keeping a close eye on markers of inflammation.<\/p>\n