{"id":88004,"date":"2019-02-19T22:22:26","date_gmt":"2019-02-20T06:22:26","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2019\/02\/single-dose-crispr-cas9-therapy-extends-lifespan-of-mice-with-hutchinson-gilford-progeria-syndrome"},"modified":"2019-02-19T22:22:26","modified_gmt":"2019-02-20T06:22:26","slug":"single-dose-crispr-cas9-therapy-extends-lifespan-of-mice-with-hutchinson-gilford-progeria-syndrome","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2019\/02\/single-dose-crispr-cas9-therapy-extends-lifespan-of-mice-with-hutchinson-gilford-progeria-syndrome","title":{"rendered":"Single-dose CRISPR\u2013Cas9 therapy extends lifespan of mice with Hutchinson\u2013Gilford progeria syndrome"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/single-dose-crispr-cas9-therapy-extends-lifespan-of-mice-with-hutchinson-gilford-progeria-syndrome.jpg\"><\/a><\/p>\n<p>Hutchinson\u2013Gilford progeria syndrome (HGPS) is a rare lethal genetic disorder characterized by symptoms reminiscent of accelerated aging. The major underlying genetic cause is a substitution mutation in the gene coding for lamin A, causing the production of a toxic isoform called progerin. Here we show that reduction of lamin A\/progerin by a single-dose systemic administration of adeno-associated virus-delivered CRISPR\u2013Cas9 components suppresses HGPS in a mouse model.<\/p>\n<p><!-- Link: <a href=\"https:\/\/www.nature.com\/articles\/s41591-019-0343-4\">https:\/\/www.nature.com\/articles\/s41591&#45;019&#45;0343&#45;4<\/a> --><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Hutchinson\u2013Gilford progeria syndrome (HGPS) is a rare lethal genetic disorder characterized by symptoms reminiscent of accelerated aging. The major underlying genetic cause is a substitution mutation in the gene coding for lamin A, causing the production of a toxic isoform called progerin. Here we show that reduction of lamin A\/progerin by a single-dose systemic administration [\u2026]<\/p>\n","protected":false},"author":511,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412,269],"tags":[],"class_list":["post-88004","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics","category-life-extension"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/88004","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/511"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=88004"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/88004\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=88004"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=88004"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=88004"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}