{"id":87960,"date":"2019-02-19T10:03:19","date_gmt":"2019-02-19T18:03:19","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2019\/02\/a-new-crispr-cas9-therapy-can-suppress-aging"},"modified":"2019-02-19T10:03:19","modified_gmt":"2019-02-19T18:03:19","slug":"a-new-crispr-cas9-therapy-can-suppress-aging","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2019\/02\/a-new-crispr-cas9-therapy-can-suppress-aging","title":{"rendered":"A new CRISPR\/Cas9 therapy can suppress aging"},"content":{"rendered":"<p><a class=\"blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/a-new-crispr-cas9-therapy-can-suppress-aging2.jpg\"><\/a><\/p>\n<p>LA JOLLA\u2014(February 18, 2019) Aging is a leading risk factor for a number of debilitating conditions, including heart disease, cancer and Alzheimer\u2019s disease, to name a few. This makes the need for anti-aging therapies all the more urgent. Now, Salk Institute researchers have developed a new gene therapy to help decelerate the aging process.<\/p>\n<p>The findings, published on February 18, 2019 in the journal <i>Nature Medicine<\/i>, highlight a novel CRISPR\/Cas9 genome-editing <a href=\"https:\/\/medicalxpress.com\/tags\/therapy\/\" rel=\"tag\" class=\"\">therapy<\/a> that can suppress the accelerated aging observed in mice with Hutchinson-Gilford progeria syndrome, a rare genetic disorder that also afflicts humans. This treatment provides important insight into the molecular pathways involved in accelerated aging, as well as how to reduce toxic proteins via <a href=\"https:\/\/medicalxpress.com\/tags\/gene+therapy\/\" rel=\"tag\" class=\"\">gene therapy<\/a>.<\/p>\n<p>\u201cAging is a complex process in which cells start to lose their functionality, so it is critical for us to find effective ways to study the molecular drivers of aging,\u201d says Juan Carlos Izpisua Belmonte, a professor in Salk\u2019s Gene Expression Laboratory and senior author of the paper. \u201cProgeria is an ideal aging model because it allows us to devise an intervention, refine it and test it again quickly.\u201d<\/p>\n<p><!-- Link: <a href=\"https:\/\/medicalxpress.com\/news\/2019-02-crisprcas9-therapy-suppress-aging.html\">https:\/\/medicalxpress.com\/news\/2019&#45;02-crisprcas9-therap...aging.html<\/a> --><\/p>\n","protected":false},"excerpt":{"rendered":"<p>LA JOLLA\u2014(February 18, 2019) Aging is a leading risk factor for a number of debilitating conditions, including heart disease, cancer and Alzheimer\u2019s disease, to name a few. This makes the need for anti-aging therapies all the more urgent. Now, Salk Institute researchers have developed a new gene therapy to help decelerate the aging process. The [\u2026]<\/p>\n","protected":false},"author":513,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412,269,47],"tags":[],"class_list":["post-87960","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics","category-life-extension","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/87960","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/513"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=87960"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/87960\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=87960"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=87960"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=87960"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}