{"id":87670,"date":"2019-02-12T07:22:23","date_gmt":"2019-02-12T15:22:23","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2019\/02\/lactate-activates-multiple-genes-that-modulate-neuronal-activity"},"modified":"2019-02-12T07:22:23","modified_gmt":"2019-02-12T15:22:23","slug":"lactate-activates-multiple-genes-that-modulate-neuronal-activity","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2019\/02\/lactate-activates-multiple-genes-that-modulate-neuronal-activity","title":{"rendered":"Lactate activates multiple genes that modulate neuronal activity"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/lactate-activates-multiple-genes-that-modulate-neuronal-activity2.jpg\"><\/a><\/p>\n<p>\u201cWe found that lactate stimulates synaptic activity-dependent genes in the short-term and genes involved in regulating neuronal excitability in the long-term,\u201d explains the first author of the paper Michael Margineanu, a KAUST Master\u2019s student.<\/p>\n<hr>\n<p>Study illustrates the links between brain energy metabolism and neuronal activity.<\/p>\n<p>A genome-wide study led by Dean Pierre Magistretti sheds light on the mechanisms through which lactate regulates long-term memory formation and neuroprotection.<\/p>\n<p>The breakdown of sugar in non-neuronal brain cells, called astrocytes, produces lactate, which gets shuttled to neurons as a source of energy. This lactate not only supports the energy demands of neurons, but also rapidly and transiently activates multiple genes that modulate neuronal activity and regulate brain function.<\/p>\n<p><!-- Link: <a href=\"https:\/\/www.news-medical.net\/news\/20190212\/Lactate-activates-multiple-genes-that-modulate-neuronal-activity.aspx\">https:\/\/www.news-medical.net\/news\/20190212\/Lactate-activates...ivity.aspx<\/a> --><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u201cWe found that lactate stimulates synaptic activity-dependent genes in the short-term and genes involved in regulating neuronal excitability in the long-term,\u201d explains the first author of the paper Michael Margineanu, a KAUST Master\u2019s student. Study illustrates the links between brain energy metabolism and neuronal activity. A genome-wide study led by Dean Pierre Magistretti sheds light [\u2026]<\/p>\n","protected":false},"author":501,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,47],"tags":[],"class_list":["post-87670","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/87670","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/501"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=87670"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/87670\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=87670"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=87670"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=87670"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}