{"id":87566,"date":"2019-02-08T15:42:22","date_gmt":"2019-02-08T23:42:22","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2019\/02\/microbiome-could-be-culprit-when-good-drugs-do-harm"},"modified":"2019-02-08T15:42:22","modified_gmt":"2019-02-08T23:42:22","slug":"microbiome-could-be-culprit-when-good-drugs-do-harm","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2019\/02\/microbiome-could-be-culprit-when-good-drugs-do-harm","title":{"rendered":"Microbiome could be culprit when good drugs do harm"},"content":{"rendered":"<p><\/p>\n<p><iframe style=\"display: block; margin: 0 auto; width: 100%; aspect-ratio: 4\/3; object-fit: contain;\" src=\"https:\/\/www.youtube.com\/embed\/LyjiVRRhIzM?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; encrypted-media; gyroscope;\n   picture-in-picture\" allowfullscreen><\/iframe><\/p>\n<p>Or bad drugs given to good people by doctors who were clueless \ud83d\ude48<\/p>\n<p>\u2018\u2019The study found that the gut microbes were responsible for producing 20 percent to 80 percent of the circulating toxic metabolites derived from the three drugs.<\/p>\n<hr>\n<p>People sometimes suffer toxic side effects from drugs that help many others. Yale scientists have identified a surprising explanation\u2014the gut microbiome.<\/p>\n<p>The research, published Feb. 8 in the journal <i>Science<\/i>, describes how bacteria in the gut can transform three drugs into harmful compounds.<\/p>\n<p>\u201cIf we can understand the microbiome\u2019s contributions to drug metabolism, we can decide which drugs to give to patients or even alter the microbiome so patients have a better response,\u201d said co-lead author Michael Zimmermann, postdoctoral fellow in the lab of senior author Andrew Goodman in the Department of Microbial Pathogenesis and the Microbial <i>Science<\/i>s Institute.<\/p>\n<div class=\"more-link-wrapper\"> <a class=\"more-link\" href=\"https:\/\/lifeboat.com\/blog\/2019\/02\/microbiome-could-be-culprit-when-good-drugs-do-harm\">Continue reading \u201cMicrobiome could be culprit when good drugs do harm\u201d | &gt;<\/a><\/div><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Or bad drugs given to good people by doctors who were clueless \ud83d\ude48 \u2018\u2019The study found that the gut microbes were responsible for producing 20 percent to 80 percent of the circulating toxic metabolites derived from the three drugs. People sometimes suffer toxic side effects from drugs that help many others. Yale scientists have identified [\u2026]<\/p>\n","protected":false},"author":501,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-87566","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/87566","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/501"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=87566"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/87566\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=87566"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=87566"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=87566"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}