{"id":84944,"date":"2018-11-20T10:02:23","date_gmt":"2018-11-20T18:02:23","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2018\/11\/inhibiting-usp13-might-prove-effective-against-parkinsons-disease"},"modified":"2018-11-20T10:02:23","modified_gmt":"2018-11-20T18:02:23","slug":"inhibiting-usp13-might-prove-effective-against-parkinsons-disease","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2018\/11\/inhibiting-usp13-might-prove-effective-against-parkinsons-disease","title":{"rendered":"Inhibiting USP13 Might Prove Effective Against Parkinson\u2019s Disease"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/inhibiting-usp13-might-prove-effective-against-parkinsons-disease.jpg\"><\/a><\/p>\n<p>Researchers at Georgetown University Medical Center discovered that the protease USP13 (ubiquitin-specific peptidase 13) plays a role in the accumulation of toxic alpha-synuclein aggregates that characterize Parkinson\u2019s disease [1].<\/p>\n<blockquote><p><b>Abstract<\/b><\/p>\n<p>Ubiquitin specific proteases (USPs) are de-ubiquitinases that control the protein ubiquitination cycle. The role of de-ubiquitinases is poorly understood in neurodegenerative diseases. We found that USP13 is overexpressed in the post-mortem Parkinson\u2019s disease (PD) brain. We investigated whether changes in USP13 levels can affect two molecules, parkin and alpha-synuclein, that are implicated in PD pathogenesis. Parkin is an E3 ubiquitin ligase that is regulated by ubiquitination and targets certain proteins for degradation, and alpha-synuclein may be ubiquitinated and recycled in the normal brain. We found that USP13 independently regulates parkin and alpha-synuclein ubiquitination in models of alpha-synucleinopathies. USP13 shRNA knockdown increases alpha-synuclein ubiquitination and clearance in a parkin-independent manner.<\/p><\/blockquote>\n<p><!-- Link: <a href=\"https:\/\/www.leafscience.org\/inhibiting-usp13-might-prove-effective-against-parkinsons-disease\/\">https:\/\/www.leafscience.org\/inhibiting-usp13-might-prove-eff...s-disease\/<\/a> --><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers at Georgetown University Medical Center discovered that the protease USP13 (ubiquitin-specific peptidase 13) plays a role in the accumulation of toxic alpha-synuclein aggregates that characterize Parkinson\u2019s disease [1]. Abstract Ubiquitin specific proteases (USPs) are de-ubiquitinases that control the protein ubiquitination cycle. The role of de-ubiquitinases is poorly understood in neurodegenerative diseases. We found that [\u2026]<\/p>\n","protected":false},"author":418,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,47],"tags":[],"class_list":["post-84944","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/84944","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/418"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=84944"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/84944\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=84944"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=84944"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=84944"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}