{"id":84612,"date":"2018-11-09T07:43:17","date_gmt":"2018-11-09T15:43:17","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2018\/11\/plasma-nad-levels-decline-significantly-with-age"},"modified":"2018-11-09T07:43:17","modified_gmt":"2018-11-09T15:43:17","slug":"plasma-nad-levels-decline-significantly-with-age","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2018\/11\/plasma-nad-levels-decline-significantly-with-age","title":{"rendered":"Plasma NAD+ Levels Decline Significantly with Age"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/plasma-nad-levels-decline-significantly-with-age.jpg\"><\/a><\/p>\n<p>Today, we want to highlight a recent, small-scale <a href=\"https:\/\/www.liebertpub.com\/doi\/10.1089\/rej.2018.2077?fbclid=IwAR3EloIozW_pDGmijW_zObYGBnslSTEnhRpMo17HSFy75AH9q8mvjun0-3A&\">study<\/a> looking at NAD+ and how it declines with age in the plasma.<\/p>\n<p>The researchers looked at various NAD+ metabolites across age groups and found that the amounts of some of them, particularly NAD+ itself, are significantly smaller in older people than younger ones [1]. This is likely due to an age-related imbalance between the cellular machinery that consumes NAD+ and the machinery that produces it, and this imbalance leads to the lower levels observed. However, it remains unclear if the resulting decline of NAD+ is due to an increase in consumption or a decrease of production.<\/p>\n<p>Other factors may also serve to reduce the amount of NAD+ in plasma, such as inflammatory signaling molecules and oxidative damage to the NAD+ molecules. The researchers also discuss the role of CD38, <a href=\"https:\/\/www.leafscience.org\/nad-and-aging\/\">a major reason why NAD+ declines<\/a> as we get older and how inhibiting it may be a potential way to boost NAD+.<\/p>\n<p><!-- Link: <a href=\"https:\/\/www.leafscience.org\/the-plasma-nad-metabolome-is-dysregulated-during-aging\/\">https:\/\/www.leafscience.org\/the-plasma-nad-metabolome-is-dys...ing-aging\/<\/a> --><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Today, we want to highlight a recent, small-scale study looking at NAD+ and how it declines with age in the plasma. The researchers looked at various NAD+ metabolites across age groups and found that the amounts of some of them, particularly NAD+ itself, are significantly smaller in older people than younger ones [1]. This is [\u2026]<\/p>\n","protected":false},"author":370,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[269],"tags":[],"class_list":["post-84612","post","type-post","status-publish","format-standard","hentry","category-life-extension"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/84612","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/370"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=84612"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/84612\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=84612"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=84612"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=84612"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}