{"id":84090,"date":"2018-10-26T10:03:06","date_gmt":"2018-10-26T17:03:06","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2018\/10\/dna-dances-in-first-explanation-of-how-genetic-material-flows-through-a-nucleus"},"modified":"2018-10-26T10:03:06","modified_gmt":"2018-10-26T17:03:06","slug":"dna-dances-in-first-explanation-of-how-genetic-material-flows-through-a-nucleus","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2018\/10\/dna-dances-in-first-explanation-of-how-genetic-material-flows-through-a-nucleus","title":{"rendered":"DNA \u2018dances\u2019 in first explanation of how genetic material flows through a nucleus"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/dna-dances-in-first-explanation-of-how-genetic-material-flows-through-a-nucleus2.jpg\"><\/a><\/p>\n<p>\u201cPrevious work mostly focused on what was going on at the microscale of DNA,\u201d says study co-author Michael Shelley, group leader for biophysical modeling at the Flatiron Institute\u2019s Center for Computational Biology in New York City and co-director of the Courant Institute\u2019s Applied Mathematics Laboratory at New York University. \u201cPeople didn\u2019t really think about what was going on at the larger scale.\u201d<\/p>\n<p>Shelley and colleagues simulated the motions of chromatin, the functional form of DNA inside the nucleus. Chromatin looks like beads on a string, with ball-like clusters of genetic material linked by strands of DNA. The researchers propose that molecular machines along the DNA cause segments of the chromatin to straighten and pull taut. This activity aligns neighboring strands to face the same direction. That alignment, in turn, results in a cascading waltz of genetic material shimmying across the nucleus.<\/p>\n<p>The dancing DNA may play a role in gene expression, replication and remodeling, though the exact effects remain unclear, the researchers reported online October 22 in <em>Proceedings of the National Academy of Sciences<\/em>.<\/p>\n<p><!-- Link: <a href=\"https:\/\/www.sciencedaily.com\/releases\/2018\/10\/181025113156.htm\">https:\/\/www.sciencedaily.com\/releases\/2018\/10\/181025113156.htm<\/a> --><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u201cPrevious work mostly focused on what was going on at the microscale of DNA,\u201d says study co-author Michael Shelley, group leader for biophysical modeling at the Flatiron Institute\u2019s Center for Computational Biology in New York City and co-director of the Courant Institute\u2019s Applied Mathematics Laboratory at New York University. \u201cPeople didn\u2019t really think about what [\u2026]<\/p>\n","protected":false},"author":501,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412,4],"tags":[],"class_list":["post-84090","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics","category-nanotechnology"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/84090","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/501"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=84090"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/84090\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=84090"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=84090"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=84090"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}