{"id":83500,"date":"2018-10-10T08:22:21","date_gmt":"2018-10-10T15:22:21","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2018\/10\/invariant-natural-killer-t-cells-might-be-the-next-step-in-cancer-therapy"},"modified":"2018-10-10T08:22:21","modified_gmt":"2018-10-10T15:22:21","slug":"invariant-natural-killer-t-cells-might-be-the-next-step-in-cancer-therapy","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2018\/10\/invariant-natural-killer-t-cells-might-be-the-next-step-in-cancer-therapy","title":{"rendered":"Invariant Natural Killer T Cells Might Be The Next Step in Cancer Therapy"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/invariant-natural-killer-t-cells-might-be-the-next-step-in-cancer-therapy.jpg\"><\/a><\/p>\n<p>Invariant natural killer T cells might lead to cheaper and more effective immunotherapy.<\/p>\n<hr>\n<p>Researchers at the Imperial College London have discovered that specifically employing invariant natural killer T cells, rather than generic T cells, in cancer immunotherapies based on chimeric antigen receptors might lead to significantly more effective, cheaper, and more easily mass-produced treatments [1].<\/p>\n<blockquote><p><b>Abstract<\/b><\/p>\n<p>Chimeric antigen receptor anti-CD19 (CAR19)-T cell immunotherapy-induced clinical remissions in CD19+ B cell lymphomas are often short lived. We tested whether CAR19-engineering of the CD1d-restricted invariant natural killer T (iNKT) cells would result in enhanced anti-lymphoma activity. CAR19-iNKT cells co-operatively activated by CD1d- and CAR19-CD19-dependent interactions are more effective than CAR19-T cells against CD1d-expressing lymphomas in vitro and in vivo. The swifter in vivo anti-lymphoma activity of CAR19-iNKT cells and their enhanced ability to eradicate brain lymphomas underpinned an improved tumor-free and overall survival. CD1D transcriptional de-repression by all-trans retinoic acid results in further enhanced cytotoxicity of CAR19-iNKT cells against CD19+ chronic lymphocytic leukemia cells. Thus, iNKT cells are a highly efficient platform for CAR-based immunotherapy of lymphomas and possibly other CD1d-expressing cancers.<\/p><\/blockquote>\n<p><!-- Link: <a href=\"https:\/\/www.leafscience.org\/invariant-natural-killer-t-cells-might-be-the-next-step-in-cancer-therapy\/\">https:\/\/www.leafscience.org\/invariant-natural-killer-t-cells...r-therapy\/<\/a> --><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Invariant natural killer T cells might lead to cheaper and more effective immunotherapy. Researchers at the Imperial College London have discovered that specifically employing invariant natural killer T cells, rather than generic T cells, in cancer immunotherapies based on chimeric antigen receptors might lead to significantly more effective, cheaper, and more easily mass-produced treatments [1]. [\u2026]<\/p>\n","protected":false},"author":418,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,38,47],"tags":[],"class_list":["post-83500","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-engineering","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/83500","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/418"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=83500"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/83500\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=83500"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=83500"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=83500"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}