{"id":82940,"date":"2018-09-24T14:42:45","date_gmt":"2018-09-24T21:42:45","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2018\/09\/the-role-of-brain-vasculature-in-neurodegenerative-disorders"},"modified":"2018-09-25T11:05:19","modified_gmt":"2018-09-25T18:05:19","slug":"the-role-of-brain-vasculature-in-neurodegenerative-disorders","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2018\/09\/the-role-of-brain-vasculature-in-neurodegenerative-disorders","title":{"rendered":"The role of brain vasculature in neurodegenerative disorders"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/the-role-of-brain-vasculature-in-neurodegenerative-disorders.jpg\"><\/a><\/p>\n<p>Adequate supply of blood and structural and functional integrity of blood vessels are key to normal brain functioning. On the other hand, cerebral blood flow shortfalls and blood\u2013brain barrier dysfunction are early findings in neurodegenerative disorders in humans and animal models. Here we first examine molecular definition of cerebral blood vessels, as well as pathways regulating cerebral blood flow and blood\u2013brain barrier integrity. Then we examine the role of cerebral blood flow and blood\u2013brain barrier in the pathogenesis of Alzheimer\u2019s disease, Parkinson\u2019s disease, Huntington\u2019s disease, amyotrophic lateral sclerosis, and multiple sclerosis. We focus on Alzheimer\u2019s disease as a platform of our analysis because more is known about neurovascular dysfunction in this disease than in other neurodegenerative disorders. Finally, we propose a hypothetical model of Alzheimer\u2019s disease biomarkers to include brain vasculature as a factor contributing to the disease onset and progression, and we suggest a common pathway linking brain vascular contributions to neurodegeneration in multiple neurodegenerative disorders.<\/p>\n<p><!-- Link: <a href=\"https:\/\/www.nature.com\/articles\/s41593-018-0234-x\">https:\/\/www.nature.com\/articles\/s41593&#45;018&#45;0234-x<\/a> --><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Adequate supply of blood and structural and functional integrity of blood vessels are key to normal brain functioning. On the other hand, cerebral blood flow shortfalls and blood\u2013brain barrier dysfunction are early findings in neurodegenerative disorders in humans and animal models. Here we first examine molecular definition of cerebral blood vessels, as well as pathways [\u2026]<\/p>\n","protected":false},"author":396,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,47],"tags":[],"class_list":["post-82940","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/82940","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/396"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=82940"}],"version-history":[{"count":1,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/82940\/revisions"}],"predecessor-version":[{"id":82987,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/82940\/revisions\/82987"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=82940"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=82940"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=82940"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}