{"id":82933,"date":"2018-09-24T08:22:21","date_gmt":"2018-09-24T15:22:21","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2018\/09\/known-drug-might-prove-effective-against-alzheimers-disease"},"modified":"2018-09-25T11:07:27","modified_gmt":"2018-09-25T18:07:27","slug":"known-drug-might-prove-effective-against-alzheimers-disease","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2018\/09\/known-drug-might-prove-effective-against-alzheimers-disease","title":{"rendered":"Known Drug Might Prove Effective Against Alzheimer\u2019s Disease"},"content":{"rendered":"

<\/a><\/p>\n

Apparently, amyloid beta drives its own production in a vicious circle.<\/p>\n

\n

In a study<\/a> at King\u2019s College London, scientists have shown that a vicious circle in which the ill-famed amyloid-beta protein stimulates its own production might be a key factor in the etiology of neurodegeneration in Alzheimer\u2019s disease; furthermore, a drug known as fasudil seems to be effective against amyloid-beta in a mice model of the disease [1].<\/p>\n

Study abstract<\/strong><\/p>\n

In Alzheimer\u2019s disease (AD), the canonical Wnt inhibitor Dickkopf-1 (Dkk1) is induced by \u03b2-amyloid (A\u03b2) and shifts the balance from canonical towards non-canonical Wnt signalling. Canonical (Wnt-\u03b2-catenin) signalling promotes synapse stability, while non-canonical (Wnt-PCP) signalling favours synapse retraction; thus A\u03b2-driven synapse loss is mediated by Dkk1. Here we show that the Amyloid Precursor Protein (APP) co-activates both arms of Wnt signalling through physical interactions with Wnt co-receptors LRP6 and Vangl2, to bi-directionally modulate synapse stability. Furthermore, activation of non-canonical Wnt signalling enhances A\u03b2 production, while activation of canonical signalling suppresses A\u03b2 production. Together, these findings identify a pathogenic-positive feedback loop in which A\u03b2 induces Dkk1 expression, thereby activating non-canonical Wnt signalling to promote synapse loss and drive further A\u03b2 production.<\/p><\/blockquote>\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

Apparently, amyloid beta drives its own production in a vicious circle. In a study at King\u2019s College London, scientists have shown that a vicious circle in which the ill-famed amyloid-beta protein stimulates its own production might be a key factor in the etiology of neurodegeneration in Alzheimer\u2019s disease; furthermore, a drug known as fasudil seems [\u2026]<\/p>\n","protected":false},"author":418,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,47],"tags":[],"class_list":["post-82933","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/82933","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/418"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=82933"}],"version-history":[{"count":1,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/82933\/revisions"}],"predecessor-version":[{"id":82994,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/82933\/revisions\/82994"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=82933"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=82933"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=82933"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}