{"id":82711,"date":"2018-09-15T17:42:31","date_gmt":"2018-09-16T00:42:31","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2018\/09\/characteristic-patterns-of-inter-and-intra-hemispheric-metabolic-connectivity-in-patients-with-stable-and-progressive-mild-cognitive-impairment-and-alzheimers-disease"},"modified":"2018-09-15T17:42:31","modified_gmt":"2018-09-16T00:42:31","slug":"characteristic-patterns-of-inter-and-intra-hemispheric-metabolic-connectivity-in-patients-with-stable-and-progressive-mild-cognitive-impairment-and-alzheimers-disease","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2018\/09\/characteristic-patterns-of-inter-and-intra-hemispheric-metabolic-connectivity-in-patients-with-stable-and-progressive-mild-cognitive-impairment-and-alzheimers-disease","title":{"rendered":"Characteristic patterns of inter- and intra-hemispheric metabolic connectivity in patients with stable and progressive mild cognitive impairment and Alzheimer\u2019s disease"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/characteristic-patterns-of-inter-and-intra-hemispheric-metabolic-connectivity-in-patients-with-stable-and-progressive-mild-cognitive-impairment-and-alzheimers-disease.jpg\"><\/a><\/p>\n<p>Alzheimer\u2019s disease (AD) is a neurodegenerative disease with characterization of deficits in progressive memory loss, cognitive and behaviour functions. Mild cognitive impairment (MCI) is a predromal stage of AD, displaying cognitive deficit but neither marked functional impairment nor satisfying established clinical criteria for dementia or probable AD. However, not all MCI patients may eventually progress to AD (progressive MCI, pMCI)<sup><a data-track=\"click\" data-track-action=\"reference anchor\" data-track-label=\"link\" data-test=\"citation-ref\" aria-label=\"Reference 2\" title=\"Ewers, M. et al. Reduced FDG-PET brain metabolism and executive function predict clinical progression in elderly healthy subjects. Neuroimage Clin 4, 45\u201352,[\/a><\/p>\n<p><a href=\"https:\/\/doi.org\/10.1016\/j.nicl.2013.10\">https:\/\/doi.org\/10.1016\/j.nicl.2013.10<\/a>.<\/p>\n<p>(2014).\" href=\"https:\/\/www.nature.com\/articles\/s41598-018-31794-8#ref-CR2\" id=\"ref-link-section-d1856e5935\"]2<\/a><\/sup>, and some remain unchanged (stable MCI, sMCI), or are recovered from. Therefore, differential diagnosis of MCI types and earlier diagnosis of AD and prediction of disease evolution are difficult<sup><a data-track=\"click\" data-track-action=\"reference anchor\" data-track-label=\"link\" data-test=\"citation-ref\" aria-label=\"Reference 4\" title=\"Grundman, M. et al. Mild cognitive impairment can be distinguished from Alzheimer disease and normal aging for clinical trials. Archives of neurology 61, 59\u201366,[\/sup><\/p>\n<p><a href=\"https:\/\/www.nature.com\/articles\/s41598-018-31794-8\" target=\"_blank\"><\/p>\n<div style=\"clear:both;\">Read more<\/div>\n<p><\/a><\/a><\/sup><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Alzheimer\u2019s disease (AD) is a neurodegenerative disease with characterization of deficits in progressive memory loss, cognitive and behaviour functions. Mild cognitive impairment (MCI) is a predromal stage of AD, displaying cognitive deficit but neither marked functional impairment nor satisfying established clinical criteria for dementia or probable AD. However, not all MCI patients may eventually progress [\u2026]<\/p>\n","protected":false},"author":396,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,47],"tags":[],"class_list":["post-82711","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/82711","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/396"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=82711"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/82711\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=82711"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=82711"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=82711"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}