{"id":82497,"date":"2018-09-11T08:42:26","date_gmt":"2018-09-11T15:42:26","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2018\/09\/molecule-appears-to-have-anti-aging-effects-on-the-vascular-system"},"modified":"2018-09-15T12:27:22","modified_gmt":"2018-09-15T19:27:22","slug":"molecule-appears-to-have-anti-aging-effects-on-the-vascular-system","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2018\/09\/molecule-appears-to-have-anti-aging-effects-on-the-vascular-system","title":{"rendered":"Molecule Appears to Have Anti-Aging Effects on the Vascular System"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/molecule-appears-to-have-anti-aging-effects-on-the-vascular-system2.jpg\"><\/a><\/p>\n<p>\u0392-hydroxybutyrate seems to prevent senescence of vascular tissue.<\/p>\n<hr>\n<p>According to a study by Georgia State University scientists, a molecule called \u03b2-hydroxybutyrate has anti-aging effects on the vascular system; more specifically, the molecule appears to prevent senescence of vascular cells by promoting cellular quiescence instead [1].<\/p>\n<blockquote><p><strong>Study abstract<\/strong><\/p>\n<p>\u03b2-hydroxybutyrate (\u03b2-HB) elevation during fasting or caloric restriction is believed to induce anti-aging effects and alleviate aging-related neurodegeneration. However, whether \u03b2-HB alters the senescence pathway in vascular cells remains unknown. Here we report that \u03b2-HB promotes vascular cell quiescence, which significantly inhibits both stress-induced premature senescence and replicative senescence through p53-independent mechanisms. Further, we identify heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) as a direct binding target of \u03b2-HB binding to hnRNP A1 markedly enhances hnRNP A1 binding with Octamer-binding transcriptional factor Oct4 mRNA, which stabilizes Oct4 mRNA and Oct4 expression. Oct4 increases Lamin B1, a key factor against DNA damage-induced senescence. Finally, fasting and intraperitoneal injection of \u03b2-HB upregulate Oct4 and Lamin B1 in both vascular smooth muscle and endothelial cells in mice in vivo.<\/p><\/blockquote>\n<p><!-- Link: <a href=\"https:\/\/www.leafscience.org\/molecule-appears-to-have-anti-aging-effects-on-the-vascular-system\/\">https:\/\/www.leafscience.org\/molecule-appears-to-have-anti-ag...ar-system\/<\/a> --><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u0392-hydroxybutyrate seems to prevent senescence of vascular tissue. According to a study by Georgia State University scientists, a molecule called \u03b2-hydroxybutyrate has anti-aging effects on the vascular system; more specifically, the molecule appears to prevent senescence of vascular cells by promoting cellular quiescence instead [1]. Study abstract \u03b2-hydroxybutyrate (\u03b2-HB) elevation during fasting or caloric restriction [\u2026]<\/p>\n","protected":false},"author":418,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,269],"tags":[],"class_list":["post-82497","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-life-extension"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/82497","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/418"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=82497"}],"version-history":[{"count":1,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/82497\/revisions"}],"predecessor-version":[{"id":82689,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/82497\/revisions\/82689"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=82497"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=82497"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=82497"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}