{"id":80829,"date":"2018-07-21T18:22:22","date_gmt":"2018-07-22T01:22:22","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2018\/07\/scientists-reverse-aging-associated-skin-wrinkles-and-hair-loss-in-a-mouse-model"},"modified":"2018-07-21T18:22:22","modified_gmt":"2018-07-22T01:22:22","slug":"scientists-reverse-aging-associated-skin-wrinkles-and-hair-loss-in-a-mouse-model","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2018\/07\/scientists-reverse-aging-associated-skin-wrinkles-and-hair-loss-in-a-mouse-model","title":{"rendered":"Scientists reverse aging-associated skin wrinkles and hair loss in a mouse model"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/scientists-reverse-aging-associated-skin-wrinkles-and-hair-loss-in-a-mouse-model.jpg\"><\/a><\/p>\n<p>BIRMINGHAM, Ala. \u2014 Wrinkled skin and hair loss are hallmarks of aging. What if they could be reversed?<\/p>\n<p>Keshav Singh, Ph.D., and colleagues have done just that, in a mouse model developed at the University of Alabama at Birmingham. When a mutation leading to mitochondrial dysfunction is induced, the mouse develops wrinkled skin and extensive, visible hair loss in a matter of weeks. When the mitochondrial function is restored by turning off the gene responsible for mitochondrial dysfunction, the mouse returns to smooth skin and thick fur, indistinguishable from a healthy mouse of the same age.<\/p>\n<p>\u201cTo our knowledge, this observation is unprecedented,\u201d said Singh, a professor of genetics in the UAB School of Medicine.<\/p>\n<p><!-- Link: <a href=\"https:\/\/www.eurekalert.org\/pub_releases\/2018-07\/uoaa-sra072018.php\">https:\/\/www.eurekalert.org\/pub_releases\/2018&#45;07\/uoaa-sra072018.php<\/a> --><\/p>\n","protected":false},"excerpt":{"rendered":"<p>BIRMINGHAM, Ala. \u2014 Wrinkled skin and hair loss are hallmarks of aging. What if they could be reversed? Keshav Singh, Ph.D., and colleagues have done just that, in a mouse model developed at the University of Alabama at Birmingham. When a mutation leading to mitochondrial dysfunction is induced, the mouse develops wrinkled skin and extensive, [\u2026]<\/p>\n","protected":false},"author":461,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412,269],"tags":[],"class_list":["post-80829","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics","category-life-extension"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/80829","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/461"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=80829"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/80829\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=80829"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=80829"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=80829"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}