{"id":80449,"date":"2018-07-07T12:22:56","date_gmt":"2018-07-07T19:22:56","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2018\/07\/scientists-discover-a-new-mechanism-that-prevents-the-proliferation-of-cancer-cells"},"modified":"2018-07-07T12:22:56","modified_gmt":"2018-07-07T19:22:56","slug":"scientists-discover-a-new-mechanism-that-prevents-the-proliferation-of-cancer-cells","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2018\/07\/scientists-discover-a-new-mechanism-that-prevents-the-proliferation-of-cancer-cells","title":{"rendered":"Scientists discover a new mechanism that prevents the proliferation of cancer cells"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/scientists-discover-a-new-mechanism-that-prevents-the-proliferation-of-cancer-cells2.jpg\"><\/a><\/p>\n<p>Canadian researchers have discovered a new and direct molecular mechanism to stop cancer cells from proliferating. In the prestigious journal <i>Nature Cell Biology<\/i>, scientists from Universit\u00e9 de Montr\u00e9al show that a disruption of a fine balance in the composition of ribosomes (huge molecules that translate the genetic code into proteins) results in a shutdown of cancer cell proliferation, triggering a process called senescence.<\/p>\n<p>\u201cRibosomes are complex machines composed of both RNAs and proteins that make all the proteins necessary for <a href=\"https:\/\/phys.org\/tags\/cells\/\" rel=\"tag\" class=\"\">cells<\/a> to grow,\u201d said UdeM biochemistry professor Gerardo Ferbeyre, the study\u2019s senior author. Cancer cells grow and proliferate relentlessly and thus require a massive amount of ribosomes, he explained. Growing cells must coordinate the production of both ribosomal RNAs and ribosomal proteins in order to assemble them together in strict proportion to each other.<\/p>\n<p>\u201cWe were surprised, however, to find that if the production of ribosomal RNA\u2013<a href=\"https:\/\/phys.org\/tags\/protein\/\" rel=\"tag\" class=\"\">protein<\/a> proportions are driven out of balance in a cancer cell, proliferation can be shut down by in a very simple and direct manner,\u201d said Ferbeyre.<\/p>\n<p><!-- Link: <a href=\"https:\/\/phys.org\/news\/2018-06-scientists-mechanism-proliferation-cancer-cells.html\">https:\/\/phys.org\/news\/2018&#45;06-scientists-mechanism-proli...cells.html<\/a> --><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Canadian researchers have discovered a new and direct molecular mechanism to stop cancer cells from proliferating. In the prestigious journal Nature Cell Biology, scientists from Universit\u00e9 de Montr\u00e9al show that a disruption of a fine balance in the composition of ribosomes (huge molecules that translate the genetic code into proteins) results in a shutdown of [\u2026]<\/p>\n","protected":false},"author":396,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412],"tags":[],"class_list":["post-80449","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/80449","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/396"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=80449"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/80449\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=80449"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=80449"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=80449"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}