{"id":79919,"date":"2018-06-21T23:02:29","date_gmt":"2018-06-22T06:02:29","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2018\/06\/new-platform-will-help-create-designer-human-proteins-in-the-lab"},"modified":"2018-06-21T23:02:29","modified_gmt":"2018-06-22T06:02:29","slug":"new-platform-will-help-create-designer-human-proteins-in-the-lab","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2018\/06\/new-platform-will-help-create-designer-human-proteins-in-the-lab","title":{"rendered":"New platform will help create designer human proteins in the lab"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/new-platform-will-help-create-designer-human-proteins-in-the-lab.jpg\"><\/a><\/p>\n<p>A group of researchers from Yale University and Agilent Technologies have developed a #syntheticbiology technique that turns bacterium E. Coli into a phosphorylated protein factory capable of churning out every known instance of this modification in human proteins.<\/p>\n<hr>\n<p>Proteins, the end product of genes, carry out life functions. Most human proteins are modified by a process called serine phosphorylation \u2014 a chemical switch that can alter their structure and function. Malfunctions in this process have been implicated in diseases such as cancer and Alzheimer\u2019s yet are difficult to detect and study. A group of researchers from Yale University and Agilent Technologies have developed a synthetic biology technique that turns bacterium <em>E. Coli<\/em> into a phosphorylated protein factory capable of churning out every known instance of this modification in human proteins.<\/p>\n<p>\u201cWe synthesized over 110,000 phosphoproteins from scratch and we can now study how they all function together,\u201d said <a href=\"https:\/\/medicine.yale.edu\/lab\/rinehart\/members\/jesse_rinehart.profile?source=news\" target=\"_blank\" class=\"\">Jesse Rinehart, associate professor of cellular and molecular physiology<\/a> at the Systems Biology Institute and senior author of the research. \u201cThis is the future of scientific research \u2014 we can build everything we study.\u201d<\/p>\n<p>Previously, researchers were only able to create a single phosphoprotein at a time. The new platform will help scientists create designer proteins by studying the impact of phosphorylation on all potential protein interactions, the authors say. \u201cBiologists want to know which proteins interact with each other because diseases can arise when these interactions go wrong,\u201d said Karl Barber, a Yale graduate student who is the first author on the study and <a href=\"https:\/\/westcampus.yale.edu\/news\/dream-come-true-yale-graduate-student-joins-inaugural-class-schmidt-science-fellows\" target=\"_blank\" class=\"\">a recently named Schmidt Science Fellow<\/a>.<\/p>\n<p><!-- Link: <a href=\"https:\/\/news.yale.edu\/2018\/06\/13\/new-platform-will-help-create-designer-human-proteins-lab?utm_content=buffercc2ad&utm_medium=social&utm_source=facebook.com&utm_campaign=buffer\">https:\/\/news.yale.edu\/2018\/06\/13\/new-platform-will-help-crea...ign=buffer<\/a> --><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A group of researchers from Yale University and Agilent Technologies have developed a #syntheticbiology technique that turns bacterium E. Coli into a phosphorylated protein factory capable of churning out every known instance of this modification in human proteins. Proteins, the end product of genes, carry out life functions. Most human proteins are modified by a [\u2026]<\/p>\n","protected":false},"author":476,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1902,11,47],"tags":[],"class_list":["post-79919","post","type-post","status-publish","format-standard","hentry","category-bioengineering","category-biotech-medical","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/79919","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/476"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=79919"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/79919\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=79919"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=79919"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=79919"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}