{"id":79837,"date":"2018-06-20T08:22:23","date_gmt":"2018-06-20T15:22:23","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2018\/06\/aggregate-form-of-%ce%b1-synuclein-leads-to-cell-death-in-parkinsons-disease"},"modified":"2018-06-21T13:01:47","modified_gmt":"2018-06-21T20:01:47","slug":"aggregate-form-of-%ce%b1-synuclein-leads-to-cell-death-in-parkinsons-disease","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2018\/06\/aggregate-form-of-%ce%b1-synuclein-leads-to-cell-death-in-parkinsons-disease","title":{"rendered":"Aggregate form of \u03b1-synuclein leads to cell death in Parkinson\u2019s Disease"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/aggregate-form-of-ceb1-synuclein-leads-to-cell-death-in-parkinsons-disease.jpg\"><\/a><\/p>\n<p>An interaction between aggregate alpha synuclein and ATP synthase implicated in Parkinson\u2019s Disease.<\/p>\n<hr>\n<p>An open-access <a href=\"https:\/\/www.nature.com\/articles\/s41467-018-04422-2\">paper<\/a> published in Nature Communications sheds light on how an accumulation of \u03b1-synuclein protein in brain cells contributes to causing Parkinson\u2019s disease. In particular, the researchers discovered how clumps of the protein damage important proteins on mitochondrial surfaces, leading to impaired energy production, swelling and bursting of the mitochondria themselves, and, ultimately, cell death [1].<\/p>\n<blockquote><p><strong>Study abstract<\/strong><\/p><\/blockquote>\n<p><!-- Link: <a href=\"https:\/\/www.leafscience.org\/mitochondrial-swelling-parkinson\/\">https:\/\/www.leafscience.org\/mitochondrial-swelling-parkinson\/<\/a> --><\/p>\n","protected":false},"excerpt":{"rendered":"<p>An interaction between aggregate alpha synuclein and ATP synthase implicated in Parkinson\u2019s Disease. An open-access paper published in Nature Communications sheds light on how an accumulation of \u03b1-synuclein protein in brain cells contributes to causing Parkinson\u2019s disease. In particular, the researchers discovered how clumps of the protein damage important proteins on mitochondrial surfaces, leading to [\u2026]<\/p>\n","protected":false},"author":418,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,47],"tags":[],"class_list":["post-79837","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/79837","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/418"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=79837"}],"version-history":[{"count":1,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/79837\/revisions"}],"predecessor-version":[{"id":79853,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/79837\/revisions\/79853"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=79837"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=79837"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=79837"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}