{"id":79329,"date":"2018-06-07T11:02:21","date_gmt":"2018-06-07T18:02:21","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2018\/06\/nad-precursor-has-therapeutic-potential-against-parkinsons-disease"},"modified":"2018-06-11T11:13:10","modified_gmt":"2018-06-11T18:13:10","slug":"nad-precursor-has-therapeutic-potential-against-parkinsons-disease","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2018\/06\/nad-precursor-has-therapeutic-potential-against-parkinsons-disease","title":{"rendered":"NAD+ Precursor Has Therapeutic Potential Against Parkinsons Disease"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/nad-precursor-has-therapeutic-potential-against-parkinsons-disease.jpg\"><\/a><\/p>\n<p>Today, we will be taking a look at a new study showing that an NAD+ precursor was able to improve mitochondrial function in cells and flies with a model of Parkinson\u2019s disease.<\/p>\n<blockquote><p>Summary<\/p>\n<p>While mitochondrial dysfunction is emerging as key in Parkinson\u2019s disease (PD), a central question remains whether mitochondria are actual disease drivers and whether boosting mitochondrial biogenesis and function ameliorates pathology. We address these questions using patient-derived induced pluripotent stem cells and Drosophila models of GBA-related PD (GBA-PD), the most common PD genetic risk. Patient neurons display stress responses, mitochondrial demise, and changes in NAD+ metabolism. NAD+ precursors have been proposed to ameliorate agerelated metabolic decline and disease. We report that increasing NAD+ via the NAD+ precursor nicotinamide riboside (NR) significantly ameliorates mitochondrial function in patient neurons. Human neurons require nicotinamide phosphoribosyltransferase (NAMPT) to maintain the NAD+ pool and utilize NRK1 to synthesize NAD+ from NAD+ precursors. Remarkably, NR prevents the age-related dopaminergic neuronal loss and motor decline in fly models of GBA-PD.<\/p><\/blockquote>\n<p><!-- Link: <a href=\"https:\/\/www.leafscience.org\/nicotinamide-riboside-has-therapeutic-potential-against-parkinsons-disease\/\">https:\/\/www.leafscience.org\/nicotinamide-riboside-has-therap...s-disease\/<\/a> --><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Today, we will be taking a look at a new study showing that an NAD+ precursor was able to improve mitochondrial function in cells and flies with a model of Parkinson\u2019s disease. Summary While mitochondrial dysfunction is emerging as key in Parkinson\u2019s disease (PD), a central question remains whether mitochondria are actual disease drivers and [\u2026]<\/p>\n","protected":false},"author":370,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412,269,47],"tags":[],"class_list":["post-79329","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics","category-life-extension","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/79329","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/370"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=79329"}],"version-history":[{"count":1,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/79329\/revisions"}],"predecessor-version":[{"id":79536,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/79329\/revisions\/79536"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=79329"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=79329"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=79329"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}