{"id":78636,"date":"2018-05-13T23:22:22","date_gmt":"2018-05-14T06:22:22","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2018\/05\/anti-aging-protein-alpha-klothos-molecular-structure-revealed"},"modified":"2018-05-17T10:11:31","modified_gmt":"2018-05-17T17:11:31","slug":"anti-aging-protein-alpha-klothos-molecular-structure-revealed","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2018\/05\/anti-aging-protein-alpha-klothos-molecular-structure-revealed","title":{"rendered":"Anti-aging protein alpha Klotho\u2019s molecular structure revealed"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/anti-aging-protein-alpha-klothos-molecular-structure-revealed.jpg\"><\/a><\/p>\n<p>DALLAS \u2013 March 29, 2018 \u2013 Researchers from UT Southwestern\u2019s Charles and Jane Pak Center for Mineral Metabolism and Clinical Research and Internal Medicine\u2019s Division of Nephrology recently published <a href=\"http:\/\/www.nature.com\/articles\/nature25451\">work<\/a> in <em>Nature<\/em> that reveals the molecular structure of the so-called \u201canti-aging\u201d protein alpha Klotho (a-Klotho) and how it transmits a hormonal signal that controls a variety of biologic processes. The investigation was performed in collaboration with scientists from New York University School of Medicine and Wenzhou Medical University in China.<\/p>\n<p>Studies at UTSW two decades ago by <a href=\"http:\/\/profiles.utsouthwestern.edu\/profile\/34979\/makoto-kuro-o.html\">Dr. Makoto Kuro-o<\/a>, Professor of Pathology, demonstrated that mice lacking either a-Klotho or the hormone FGF23 suffered from premature and multiple organ failure as well as other conditions, including early onset cardiovascular disease, cancer, and cognitive decline. Because defects in a-Klotho lead to symptoms seen in aging, researchers inferred that a-Klotho suppresses aging, leading to great interest in how the a-Klotho protein might work together with the hormone FGF23 to fulfill their roles.<\/p>\n<p>A-Klotho can exist on the surface of a cell or can be released from the cell and circulate in body fluids, including the blood, as soluble a-Klotho. The cell-attached form and the circulating form of a-Klotho were previously and universally believed to serve completely different functions.<\/p>\n<p><!-- Link: <a href=\"http:\/\/www.utsouthwestern.edu\/newsroom\/articles\/year-2018\/anti-aging-protein.html\">http:\/\/www.utsouthwestern.edu\/newsroom\/articles\/year-2018\/an...otein.html<\/a> --><\/p>\n","protected":false},"excerpt":{"rendered":"<p>DALLAS \u2013 March 29, 2018 \u2013 Researchers from UT Southwestern\u2019s Charles and Jane Pak Center for Mineral Metabolism and Clinical Research and Internal Medicine\u2019s Division of Nephrology recently published work in Nature that reveals the molecular structure of the so-called \u201canti-aging\u201d protein alpha Klotho (a-Klotho) and how it transmits a hormonal signal that controls a [\u2026]<\/p>\n","protected":false},"author":476,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,269,47],"tags":[],"class_list":["post-78636","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-life-extension","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/78636","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/476"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=78636"}],"version-history":[{"count":1,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/78636\/revisions"}],"predecessor-version":[{"id":78733,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/78636\/revisions\/78733"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=78636"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=78636"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=78636"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}