{"id":77970,"date":"2018-04-21T15:03:13","date_gmt":"2018-04-21T22:03:13","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2018\/04\/peripheral-elevation-of-a-klotho-fragment-enhances-brain-function-and-resilience-in-young-aging-and-%ce%b1-synuclein-transgenic-mice"},"modified":"2018-04-21T15:03:13","modified_gmt":"2018-04-21T22:03:13","slug":"peripheral-elevation-of-a-klotho-fragment-enhances-brain-function-and-resilience-in-young-aging-and-%ce%b1-synuclein-transgenic-mice","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2018\/04\/peripheral-elevation-of-a-klotho-fragment-enhances-brain-function-and-resilience-in-young-aging-and-%ce%b1-synuclein-transgenic-mice","title":{"rendered":"Peripheral Elevation of a Klotho Fragment Enhances Brain Function and Resilience in Young, Aging, and \u03b1-Synuclein Transgenic Mice"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/peripheral-elevation-of-a-klotho-fragment-enhances-brain-function-and-resilience-in-young-aging-and-ceb1-synuclein-transgenic-mice.jpg\"><\/a><\/p>\n<p>Peripheral Elevation of a #Klotho Fragment Enhances Brain Function and Resilience in Young, Aging, and \u03b1-Synuclein Transgenic Mice.<\/p>\n<hr>\n<p>Klotho is a longevity factor associated with cognitive enhancement when genetically and widely overexpressed over the lifetime of mice. Leon et al. show that peripheral delivery of a klotho fragment, \u03b1KL-F, acutely enhances cognition and neural resilience in young, aging, and disease model mice, establishing its therapeutic relevance and dissecting its underlying mechanisms.<\/p>\n<p><!-- Link: <a href=\"http:\/\/www.cell.com\/cell-reports\/fulltext\/S2211-1247(17)30990-7\">http:\/\/www.cell.com\/cell-reports\/fulltext\/S2211&#45;1247(17)30990&#45;7<\/a> --><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Peripheral Elevation of a #Klotho Fragment Enhances Brain Function and Resilience in Young, Aging, and \u03b1-Synuclein Transgenic Mice. Klotho is a longevity factor associated with cognitive enhancement when genetically and widely overexpressed over the lifetime of mice. Leon et al. show that peripheral delivery of a klotho fragment, \u03b1KL-F, acutely enhances cognition and neural resilience [\u2026]<\/p>\n","protected":false},"author":476,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412,269,47],"tags":[],"class_list":["post-77970","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics","category-life-extension","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/77970","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/476"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=77970"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/77970\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=77970"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=77970"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=77970"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}