{"id":77837,"date":"2018-04-16T02:23:04","date_gmt":"2018-04-16T09:23:04","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2018\/04\/cancer-not-only-mutates-but-evolves-other-mechanisms-to-beat-drugs"},"modified":"2018-04-16T02:23:04","modified_gmt":"2018-04-16T09:23:04","slug":"cancer-not-only-mutates-but-evolves-other-mechanisms-to-beat-drugs","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2018\/04\/cancer-not-only-mutates-but-evolves-other-mechanisms-to-beat-drugs","title":{"rendered":"Cancer not only mutates but evolves other mechanisms to beat drugs"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/cancer-not-only-mutates-but-evolves-other-mechanisms-to-beat-drugs.jpg\"><\/a><\/p>\n<p>Cancer can be triggered by different causes. Melanoma is usually induced by the sun, by dangerous ultraviolet light damage. In the majority of cases, UV damage leaves a unique mutational footprint behind and as a result unstoppable cell proliferation is induced.<\/p>\n<p>UV damage gives rise to point mutations \u2013 changes in a single letter of the 3 billion letter human genome. These mutations can <a class=\"\" href=\"http:\/\/dx.doi.org\/10.1016\/j.neo.2016.01.003\" rel=\"nofollow\" target=\"_blank\">interfere with signals<\/a> that tell cells when to grow and divide and when to stop. Mutations in a protein called <a class=\"\" href=\"http:\/\/dx.doi.org\/10.1038\/srep07857\" rel=\"nofollow\" target=\"_blank\">BRAF<\/a>, a major signaling regulator, cause growth signals to be stuck in the \u201con\u201d position and drive cancer development.<\/p>\n<p>Though scientists have managed to come up with drugs that target and turn off aberrant BRAF signaling, cancer cells are clever. They learn to adapt to these BRAF-inhibitors. Today, many patients respond to cancer treatment very positively at first. However, unfortunately many ultimately develop resistance and metastases.<\/p>\n<p><!-- Link: <a href=\"https:\/\/scroll.in\/pulse\/875672\/cancer-not-only-mutates-but-evolves-other-mechanisms-to-beat-drugs\">https:\/\/scroll.in\/pulse\/875672\/cancer-not-only-mutates-but-e...beat-drugs<\/a> --><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Cancer can be triggered by different causes. Melanoma is usually induced by the sun, by dangerous ultraviolet light damage. In the majority of cases, UV damage leaves a unique mutational footprint behind and as a result unstoppable cell proliferation is induced. UV damage gives rise to point mutations \u2013 changes in a single letter of [\u2026]<\/p>\n","protected":false},"author":396,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-77837","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/77837","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/396"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=77837"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/77837\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=77837"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=77837"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=77837"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}