{"id":76854,"date":"2018-03-12T09:22:42","date_gmt":"2018-03-12T16:22:42","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2018\/03\/a-protein-that-shows-the-difference-between-cancer-and-non-cancer-cells"},"modified":"2018-03-12T12:00:25","modified_gmt":"2018-03-12T19:00:25","slug":"a-protein-that-shows-the-difference-between-cancer-and-non-cancer-cells","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2018\/03\/a-protein-that-shows-the-difference-between-cancer-and-non-cancer-cells","title":{"rendered":"A Protein that Shows the Difference Between Cancer and Non-cancer Cells"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/a-protein-that-shows-the-difference-between-cancer-and-non-cancer-cells.jpg\"><\/a><\/p>\n<p>Researchers have identified a protein that is different between healthy and cancerous cells, offering a potential target for therapeutic interventions.<\/p>\n<blockquote><p><strong>Abstract<\/strong><\/p>\n<p>Sorting nexins anchor trafficking machines to membranes by binding phospholipids. The paradigm of the superfamily is sorting nexin 3 (SNX3), which localizes to early endosomes by recognizing phosphatidylinositol 3-phosphate (PI3P) to initiate retromer-mediated segregation of cargoes to the trans-Golgi network (TGN). Here we report the solution structure of full length human SNX3, and show that PI3P recognition is accompanied by bilayer insertion of a proximal loop in its extended Phox homology (PX) domain. Phosphoinositide (PIP) binding is completely blocked by cancer-linked phosphorylation of a conserved serine beside the stereospecific PI3P pocket. This \u201cPIP-stop\u201d releases endosomal SNX3 to the cytosol, and reveals how protein kinases control membrane assemblies. It constitutes a widespread regulatory element found across the PX superfamily and throughout evolution including of fungi and plants.<\/p><\/blockquote>\n<p><!-- Link: <a href=\"https:\/\/www.leafscience.org\/a-protein-that-shows-the-difference-between-cancer-and-non-cancer-cells\/\">https:\/\/www.leafscience.org\/a-protein-that-shows-the-differe...cer-cells\/<\/a> --><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers have identified a protein that is different between healthy and cancerous cells, offering a potential target for therapeutic interventions. Abstract Sorting nexins anchor trafficking machines to membranes by binding phospholipids. The paradigm of the superfamily is sorting nexin 3 (SNX3), which localizes to early endosomes by recognizing phosphatidylinositol 3-phosphate (PI3P) to initiate retromer-mediated segregation [\u2026]<\/p>\n","protected":false},"author":370,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,385],"tags":[],"class_list":["post-76854","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-evolution"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/76854","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/370"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=76854"}],"version-history":[{"count":1,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/76854\/revisions"}],"predecessor-version":[{"id":76860,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/76854\/revisions\/76860"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=76854"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=76854"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=76854"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}