{"id":75654,"date":"2018-01-30T08:42:52","date_gmt":"2018-01-30T16:42:52","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2018\/01\/reduced-gbp1-causes-mitochondrial-dysfunction-and-cellular-senescence-in-macrophages"},"modified":"2018-01-30T08:42:52","modified_gmt":"2018-01-30T16:42:52","slug":"reduced-gbp1-causes-mitochondrial-dysfunction-and-cellular-senescence-in-macrophages","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2018\/01\/reduced-gbp1-causes-mitochondrial-dysfunction-and-cellular-senescence-in-macrophages","title":{"rendered":"Reduced Gbp1 causes mitochondrial dysfunction and cellular senescence in macrophages"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/reduced-gbp1-causes-mitochondrial-dysfunction-and-cellular-senescence-in-macrophages.jpg\"><\/a><\/p>\n<p>We have talked about the polarization of macrophages in a number of previous <a href=\"https:\/\/www.leafscience.org\/tag\/polarization\/\">articles<\/a>, but, in short, macrophages can have multiple behavioral profiles that determine what roles they play; this is known as polarization. A new study has identified a regulatory protein that controls this process.<\/p>\n<p><strong>Macrophage Polarization<\/strong><\/p>\n<p>For the purposes of this article, we are interested in the M1 and M2 polarization. The M1 type is pro-inflammatory and aggressive towards invading pathogens, while the M2 type of macrophage is anti-inflammatory in nature, suppressing inflammatory responses and facilitating tissue repair.<\/p>\n<p><!-- Link: <a href=\"https:\/\/www.leafscience.org\/gbp1-causes-macrophage-dysfunction\/\">https:\/\/www.leafscience.org\/gbp1-causes-macrophage-dysfunction\/<\/a> --><\/p>\n","protected":false},"excerpt":{"rendered":"<p>We have talked about the polarization of macrophages in a number of previous articles, but, in short, macrophages can have multiple behavioral profiles that determine what roles they play; this is known as polarization. A new study has identified a regulatory protein that controls this process. Macrophage Polarization For the purposes of this article, we [\u2026]<\/p>\n","protected":false},"author":370,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-75654","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/75654","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/370"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=75654"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/75654\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=75654"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=75654"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=75654"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}