{"id":75101,"date":"2018-01-10T09:22:35","date_gmt":"2018-01-10T17:22:35","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2018\/01\/ai-can-warn-researchers-where-crispr-might-make-a-mistake"},"modified":"2018-01-14T11:02:25","modified_gmt":"2018-01-14T19:02:25","slug":"ai-can-warn-researchers-where-crispr-might-make-a-mistake","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2018\/01\/ai-can-warn-researchers-where-crispr-might-make-a-mistake","title":{"rendered":"AI can warn researchers where CRISPR might make a mistake"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/ai-can-warn-researchers-where-crispr-might-make-a-mistake.jpg\"><\/a><\/p>\n<p>Microsoft has <a href=\"https:\/\/crispr.ml\/\">built an AI tool<\/a> that predicts the accuracy of CRISPR so that researchers can avoid making incorrect edits of DNA.<\/p>\n<p><strong>Missing the target:<\/strong> CRISPR uses two components: a cutting protein and a guide RNA that directs it to the part of a genome you want to cut. The guide RNA is about 20 letters long. Problem is, multiple sites in a genome can have the same series of letters, so CRISPR could snip the wrong section\u2014known as an \u201coff target\u201d effect.<\/p>\n<p><strong>Why that matters:<\/strong> Off-target effects are one of the biggest safety concerns with CRISPR. Making incorrect cuts in a genome could, say, switch on a cancer-causing gene.<\/p>\n<p><!-- Link: <a href=\"https:\/\/www.technologyreview.com\/the-download\/609941\/ai-can-warn-researchers-where-crispr-might-make-a-mistake\/\">https:\/\/www.technologyreview.com\/the-download\/609941\/ai-can-...a-mistake\/<\/a> --><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Microsoft has built an AI tool that predicts the accuracy of CRISPR so that researchers can avoid making incorrect edits of DNA. Missing the target: CRISPR uses two components: a cutting protein and a guide RNA that directs it to the part of a genome you want to cut. The guide RNA is about 20 [\u2026]<\/p>\n","protected":false},"author":354,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,6],"tags":[],"class_list":["post-75101","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-robotics-ai"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/75101","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/354"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=75101"}],"version-history":[{"count":1,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/75101\/revisions"}],"predecessor-version":[{"id":75133,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/75101\/revisions\/75133"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=75101"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=75101"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=75101"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}