{"id":73917,"date":"2017-11-23T11:42:33","date_gmt":"2017-11-23T19:42:33","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2017\/11\/crispr-can-now-hitch-a-ride-on-nanoparticles-to-battle-disease"},"modified":"2017-12-02T12:02:28","modified_gmt":"2017-12-02T20:02:28","slug":"crispr-can-now-hitch-a-ride-on-nanoparticles-to-battle-disease","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2017\/11\/crispr-can-now-hitch-a-ride-on-nanoparticles-to-battle-disease","title":{"rendered":"CRISPR Can Now Hitch a Ride on Nanoparticles to Battle Disease"},"content":{"rendered":"<p><\/p>\n<p><iframe style=\"display: block; margin: 0 auto; width: 100%; aspect-ratio: 4\/3; object-fit: contain;\" src=\"https:\/\/www.youtube.com\/embed\/xUb8AqCHPGc?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; encrypted-media; gyroscope;\n   picture-in-picture\" allowfullscreen><\/iframe><\/p>\n<p>Yet CRISPR has a dirty secret: there\u2019s really no perfect way to deliver the \u201cmolecular scissors\u201d safely into cells. Most methods currently rely on viruses: the DNA that encodes the CRISPR machinery is spliced into a \u201cviral vector\u201d then injected into the troubled tissue.<\/p>\n<p>That\u2019s all well and good for diseases that affect blood and muscle. But for destinations buried deep within the body, delivery becomes a serious issue.<\/p>\n<p>Yin\u2019s workaround wasn\u2019t ideal: he shot <a href=\"https:\/\/www.nature.com\/articles\/nbt.2884\">two milliliters<\/a> of solution containing the CRISPR machinery into the mice\u2019s veins using incredibly high pressure. The human equivalent? Your entire blood volume, injected in just five minutes.<\/p>\n<p><!-- Link: <a href=\"https:\/\/singularityhub.com\/2017\/11\/22\/crispr-can-now-hitch-a-ride-on-nanoparticles-to-battle-disease\/?utm_source=Singularity+Hub+Newsletter&utm_campaign=6747da4de5-Hub_Daily_Newsletter&utm_medium=email&utm_term=0_f0cf60cdae-6747da4de5-58264949#sm.001mgkb1l17fueqrzlc256z5wislv\">https:\/\/singularityhub.com\/2017\/11\/22\/crispr-can-now-hitch-a...256z5wislv<\/a> --><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Yet CRISPR has a dirty secret: there\u2019s really no perfect way to deliver the \u201cmolecular scissors\u201d safely into cells. Most methods currently rely on viruses: the DNA that encodes the CRISPR machinery is spliced into a \u201cviral vector\u201d then injected into the troubled tissue. That\u2019s all well and good for diseases that affect blood and [\u2026]<\/p>\n","protected":false},"author":440,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,4],"tags":[],"class_list":["post-73917","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-nanotechnology"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/73917","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/440"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=73917"}],"version-history":[{"count":1,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/73917\/revisions"}],"predecessor-version":[{"id":74117,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/73917\/revisions\/74117"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=73917"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=73917"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=73917"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}