{"id":35758,"date":"2017-03-31T14:42:40","date_gmt":"2017-03-31T21:42:40","guid":{"rendered":"http:\/\/lifeboat.com\/blog\/2017\/03\/how-to-avoid-the-adverse-reactions-of-senolytics-through-better-design"},"modified":"2017-04-25T19:51:52","modified_gmt":"2017-04-26T02:51:52","slug":"how-to-avoid-the-adverse-reactions-of-senolytics-through-better-design","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2017\/03\/how-to-avoid-the-adverse-reactions-of-senolytics-through-better-design","title":{"rendered":"How to avoid the adverse reactions of senolytics through better design"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/how-to-avoid-the-adverse-reactions-of-senolytics-through-better-design2.jpg\"><\/a><\/p>\n<p>Another biomarker of senescent cells could be <a href=\"https:\/\/en.wikipedia.org\/wiki\/P16\" target=\"_blank\" rel=\"nofollow\">p16<\/a>, a protein whose levels increase when cells stop dividing if old and also a protein whose gene is turned off in many human cancers.<\/p>\n<p>Coming back to our topic \u2013 designing senolytics that avoid the apoptosis of young, healthy cells \u2013 the ideal senolytic should accomplish two things: \u2013turn on p53 at increased levels to determine stubborn, senescent cells to commit suicide \u2013do that on senescent cells only.<\/p>\n<p>And in order to accomplish the second part, such a drug should be \u2018programmed\u2019 to only act on those cells where it recognizes senescence-associated biomarkers. There is no single biomarker today that stains positive or negative on all types of senescence cells, but increased levels of beta-galactosidase and p16 proteins could be a welcome start to identify old cells in vivo when designing such a drug.<\/p>\n<p><!-- Link: <a href=\"http:\/\/longevityletter.com\/how-to-avoid-the-adverse-reactions-of-senolytics-through-better-design\/\">http:\/\/longevityletter.com\/how-to-avoid-the-adverse-reaction...er-design\/<\/a> --><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Another biomarker of senescent cells could be p16, a protein whose levels increase when cells stop dividing if old and also a protein whose gene is turned off in many human cancers. Coming back to our topic \u2013 designing senolytics that avoid the apoptosis of young, healthy cells \u2013 the ideal senolytic should accomplish two [\u2026]<\/p>\n","protected":false},"author":388,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,269],"tags":[],"class_list":["post-35758","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-life-extension"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/35758","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/388"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=35758"}],"version-history":[{"count":2,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/35758\/revisions"}],"predecessor-version":[{"id":48322,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/35758\/revisions\/48322"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=35758"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=35758"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=35758"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}