{"id":32223,"date":"2016-11-27T10:47:46","date_gmt":"2016-11-27T18:47:46","guid":{"rendered":"http:\/\/lifeboat.com\/blog\/2016\/11\/tissue-damage-and-senescence-provide-critical-signals-for-cellular-reprogramming-in-vivo"},"modified":"2017-06-04T14:01:20","modified_gmt":"2017-06-04T21:01:20","slug":"tissue-damage-and-senescence-provide-critical-signals-for-cellular-reprogramming-in-vivo","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2016\/11\/tissue-damage-and-senescence-provide-critical-signals-for-cellular-reprogramming-in-vivo","title":{"rendered":"Tissue damage and senescence provide critical signals for cellular reprogramming in vivo"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/tissue-damage-and-senescence-provide-critical-signals-for-cellular-reprogramming-in-vivo.gif\"><\/a><\/p>\n<p>More developments in senescent cell signalling published this month.<\/p>\n<hr>\n<p>Differentiated cells in a culture dish can assume a new identity when manipulated to express four transcription factors. This \u201creprogramming\u201d process has sparked interest because conceivably it could be harnessed as a therapeutic strategy for tissue regeneration. Mosteiro et al. used a mouse model to study the signals that promote cell reprogramming in vivo. They found that the factors that trigger reprogramming in vitro do the same in vivo; however, they also inflict cell damage. The damaged cells enter a state of senescence and begin secreting certain factors that promote reprogramming, including an inflammatory cytokine called interleukin-6. Thus, in the physiological setting, cell senescence may create a tissue context that favors reprogramming of neighboring cells.<\/p>\n<p><!-- Link: <a href=\"http:\/\/science.sciencemag.org\/content\/354\/6315\/aaf4445.full.pdf+html\">http:\/\/science.sciencemag.org\/content\/354\/6315\/aaf4445.full.pdf+html<\/a> --><\/p>\n","protected":false},"excerpt":{"rendered":"<p>More developments in senescent cell signalling published this month. Differentiated cells in a culture dish can assume a new identity when manipulated to express four transcription factors. This \u201creprogramming\u201d process has sparked interest because conceivably it could be harnessed as a therapeutic strategy for tissue regeneration. Mosteiro et al. used a mouse model to study [\u2026]<\/p>\n","protected":false},"author":370,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-32223","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/32223","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/370"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=32223"}],"version-history":[{"count":2,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/32223\/revisions"}],"predecessor-version":[{"id":65698,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/32223\/revisions\/65698"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=32223"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=32223"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=32223"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}